dc.contributor.author | Ortola Vidal, María Del Rosario | |
dc.contributor.author | García García-Esquinas, Esther | |
dc.contributor.author | Buño Soto, Antonio | |
dc.contributor.author | Carballo Casla, Adrián | |
dc.contributor.author | Sotos Prieto, Mercedes | |
dc.contributor.author | Banegas Banegas, José Ramón | |
dc.contributor.author | Rodríguez Artalejo, Fernando | |
dc.date.accessioned | 2022-07-21T07:20:48Z | |
dc.date.available | 2022-07-21T07:20:48Z | |
dc.date.issued | 2022-06-01 | |
dc.identifier.citation | Addiction 117.6 (2022): 1647-1657 | es_ES |
dc.identifier.issn | 0965-2140 (print) | es_ES |
dc.identifier.issn | 1360-0443 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/703241 | |
dc.description.abstract | Aims: To examine the association of alcohol consumption patterns with growth differentiation factor 15 (GDF-15) in older drinkers, separately among individuals with cardiovascular disease (CVD)/diabetes and those without them, as GDF-15 is a strong biomarker of chronic disease burden. Design: Cross-sectional study. Setting: Population-based study in Madrid (Spain). Participants: A total of 2051 life-time drinkers aged 65+ years included in the Seniors-ENRICA-2 study in 2015–17. Participants’ mean age was 71.4 years and 55.4% were men. Measurements: According to their average life-time alcohol intake, participants were classified as occasional (≤ 1.43 g/day), low-risk (men: > 1.43–20 g/day; women: > 1.43–10 g/day), moderate-risk (men: > 20–40 g/day; women: > 10–20 g/day) and high-risk drinkers (men: > 40 g/day; women: > 20 g/day; or binge drinkers). We also ascertained wine preference (> 80% of alcohol derived from wine), drinking with meals and adherence to a Mediterranean drinking pattern (MDP) defined as low-risk drinking, wine preference and one of the following: drinking only with meals; higher adherence to the Mediterranean diet; or any of these. Findings: In participants without CVD/diabetes, GDF-15 increased by 0.27% [95% confidence interval (CI) = 0.06%, 0.48%] per 1 g/day increment in alcohol among high-risk drinkers, but there was no clear evidence of association in those with lower intakes or in the overall group, or across categories of alcohol consumption status. Conversely, among those with CVD/diabetes, GDF-15 rose by 0.19% (95% CI = 0.05%, 0.33%) per 1 g/day increment in the overall group and GDF-15 was 26.89% (95% CI = 12.93%, 42.58%) higher in high-risk versus low-risk drinkers. Drinking with meals did not appear to be related to GDF-15, but among those without CVD/diabetes, wine preference and adherence to the MDP were associated with lower GDF-15, especially when combined with high adherence to the Mediterranean diet. Conclusions: Among older life-time drinkers in Madrid, Spain, high-risk drinking was positively associated with growth differentiation factor 15 (a biomarker of chronic disease burden). There was inconclusive evidence of a beneficial association for low-risk consumption | en_US |
dc.description.sponsorship | Fundacion Francisco Soria Melguizo, Grant/
Award Number: MITOFUN project; Instituto
de Salud Carlos III, State Secretary of R+D+I
and FEDER/FSE, Grant/Award Numbers: 16/
1512, 16/609, 18/287, 19/319; Plan Nacional
sobre Drogas, Ministry of Health of Spain,
Grant/Award Number: 2020/17; Roche
Diagnostics International; REACT EU Program,
Comunidad de Madrid and European Regional
Development Fund (ERDF), European Union:
FACINGLCOVID-CM project, Comunidad de
Madrid and European Regional Development
Fund (ERDF), European Union; Universidad
Autonoma de Madrid; Ministry of Science,
Innovation and Universities, Grant/Award
Number: RYC-2018-025069-I | en_US |
dc.format.extent | 11 pag. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | en |
dc.publisher | Wiley | es_ES |
dc.relation.ispartof | Addiction | en_US |
dc.rights | © 2022 The Authors | en_US |
dc.subject.other | Alcohol | es_ES |
dc.subject.other | GDF-15 | es_ES |
dc.subject.other | Life-time alcohol intake | en_US |
dc.subject.other | Mediterranean drinking pattern | en_US |
dc.subject.other | Older adults | en_US |
dc.subject.other | Population-based study | en_US |
dc.title | Alcohol consumption patterns and growth differentiation factor 15 among life-time drinkers aged 65+ years in Spain: a cross-sectional study | en_US |
dc.type | article | en_US |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.1111/add.15809 | es_ES |
dc.identifier.doi | 10.1111/add.15809 | es_ES |
dc.identifier.publicationfirstpage | 1647 | es_ES |
dc.identifier.publicationissue | 6 | es_ES |
dc.identifier.publicationlastpage | 1657 | es_ES |
dc.identifier.publicationvolume | 117 | es_ES |
dc.relation.projectID | Gobierno de España. RYC-2018-025069-I | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | es_ES |
dc.rights.cc | Reconocimiento – NoComercial | es_ES |
dc.rights.accessRights | openAccess | en_US |