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dc.contributor.authorClarembaux Badell, Luis Carlos 
dc.contributor.authorBaladrón de Juan, Pablo 
dc.contributor.authorGabilondo, Hugo
dc.contributor.authorRubio Ferrera, Irene
dc.contributor.authorMillán, Irene
dc.contributor.authorEstella, Carlos
dc.contributor.authorValverde Ortega, Félix S.
dc.contributor.authorMonedero Cobeta, Ignacio 
dc.contributor.authorThor, Stefan
dc.contributor.authorBenito Sipos, Jonathan 
dc.contributor.otherUAM. Departamento de Biologíaes_ES
dc.contributor.otherUAM. Departamento de Biología Moleculares_ES
dc.contributor.otherUAM. Departamento de Fisiologíaes_ES
dc.date.accessioned2022-09-30T11:28:13Z
dc.date.available2022-09-30T11:28:13Z
dc.date.issued2022-07-07
dc.identifier.citationDevelopmental Neurobiology 82.6 (2022): 495-504en_US
dc.identifier.issn1932-8451 (print)en_US
dc.identifier.issn1932-846X (online)en_US
dc.identifier.urihttp://hdl.handle.net/10486/704332
dc.description.abstractA striking feature of the nervous system pertains to the appearance of different neural cell subtypes at different axial levels. Studies in the Drosophila central nervous system reveal that one mechanism underlying such segmental differences pertains to the segment-specific removal of cells by programmed cell death (PCD). One group of genes involved in segment-specific PCD is the Hox homeotic genes. However, while segment-specific PCD is highly precise, Hox gene expression is evident in gradients, raising the issue of how the Hox gene function is precisely gated to trigger PCD in specific segments at the outer limits of Hox expression. The Drosophila Va neurons are initially generated in all nerve cord segments but removed by PCD in posterior segments. Va PCD is triggered by the posteriorly expressed Hox gene Abdominal-B (Abd-B). However, Va PCD is highly reproducible despite exceedingly weak Abd-B expression in the anterior frontiers of its expression. Here, we found that the transcriptional cofactor Dachshund supports Abd-B-mediated PCD in its anterior domain. In vivo bimolecular fluorescence complementation analysis lends support to the idea that the Dachshund/Abd-B interplay may involve physical interactions. These findings provide an example of how combinatorial codes of transcription factors ensure precision in Hox-mediated PCD in specific segments at the outer limits of Hox expressionen_US
dc.description.sponsorshipMinisterio de Ciencia y Educación, Grant/Award Number: PID2019-110952GB-I00es_ES
dc.format.extent10 pag.es_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen
dc.publisherWileyen_US
dc.relation.ispartofDevelopmental Neurobiologyen_US
dc.rights© 2022 The Authorsen_US
dc.subject.otherCell diversityen_US
dc.subject.otherDrosophilaen_US
dc.subject.otherHox frontier assistanten_US
dc.subject.otherHox genesen_US
dc.subject.otherNeuronal subtype specificationen_US
dc.subject.otherTerminal differentiationen_US
dc.titleDachshund acts with Abdominal-B to trigger programmed cell death in the Drosophila central nervous system at the frontiers of Abd-B expressionen_US
dc.typearticleen_US
dc.subject.ecienciaBiología y Biomedicina / Biologíaes_ES
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttps://doi.org/10.1002/dneu.22894en_US
dc.identifier.doi10.1002/dneu.22894
dc.identifier.publicationfirstpage495es_ES
dc.identifier.publicationissue6es_ES
dc.identifier.publicationlastpage504es_ES
dc.identifier.publicationvolume82es_ES
dc.relation.projectIDGobierno de España. PID2019-110952GB-I00es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen_US
dc.rights.ccReconocimiento – NoComercial – SinObraDerivadaes_ES
dc.rights.accessRightsopenAccessen_US
dc.facultadUAMFacultad de Cienciases_ES
dc.facultadUAMFacultad de Medicinaes_ES
dc.institutoUAMCentro de Biología Molecular Severo Ochoa (CBMSO)es_ES


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