HPLC method with electrochemical detection on gold electrode for simultaneous determination of different antimicrobial agents in cosmetics
EntityUAM. Departamento de Química Analítica y Análisis Instrumental
10.1016/j.microc.2022.107881Microchemical Journal 182 (2022): 107881
ISSN0026-265X (print); 1095-9149 (online)
Funded byLucía Abad thanks to Universidad Autonoma ´ de Madrid for the predoctoral fellowship (FPI-UAM program). Sergio Lucas-Sanchez ´ acknowledges to Comunidad de Madrid and European Social Fund for the contracts PEJ-2018-AI/BIO-11845 through the Youth Employment Initiative (YEI)
SubjectsAntimicrobial agents; Cosmetics; Electrochemical detection; Gold electrode; HPLC; Química
Rights© 2022 The Authors
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Antimicrobial agents are added to a wide variety of products such as cosmetics to reduce the risk of microbial contamination and ensure the suitability and safety of the product. However, recent studies have shown that these compounds can have negative effects on human health and the environment. Therefore, it is crucial to develop analytical methods to control the amount of these compounds in personal care products to guarantee human health and product quality. This paper presents an HPLC method with electrochemical detection using a gold electrode for the determination of the most used antimicrobial agents in cosmetic products: methylparaben (MP), 4-hydroxybenzoic acid (4-HBA), phenoxyethanol (PE) and methylisothiazolinone (MIT). For this purpose, the electrochemical response of these compounds was evaluated on the gold electrode. The optimal electrochemical detection of MP, 4-HBA; PE and MIT was performed at pH 2 and + 1.50 V (vs Ag/AgCl). Under the optimal separation and detection conditions, limits of detection (LODs) between 10 and 110 μg L− 1 were obtained. These LODs are lower than those previously reported for other HPLC methods with mass spectrometry and diode-array detectors. Cosmetic products with different compositions were successfully analysed with the proposed HPLC method obtaining recoveries between 76 % and 119 %
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Google Scholar:Abad Gil, Lucía - Lucas Sánchez, Sergio - Jesús Gismera, M. - Sevilla Escribano, M. Teresa - Procopio, Jesús R.
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