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dc.contributor.authorAbad Gil, Lucía 
dc.contributor.authorLucas Sánchez, Sergio
dc.contributor.authorJesús Gismera, M.
dc.contributor.authorSevilla Escribano, M. Teresa 
dc.contributor.authorProcopio, Jesús R.
dc.contributor.otherUAM. Departamento de Química Analítica y Análisis Instrumentales_ES
dc.date.accessioned2022-10-03T08:13:19Z
dc.date.available2022-10-03T08:13:19Z
dc.date.issued2022-08-24
dc.identifier.citationMicrochemical Journal 182 (2022): 107881en_US
dc.identifier.issn0026-265X (print)en_US
dc.identifier.issn1095-9149 (online)en_US
dc.identifier.urihttp://hdl.handle.net/10486/704348
dc.description.abstractAntimicrobial agents are added to a wide variety of products such as cosmetics to reduce the risk of microbial contamination and ensure the suitability and safety of the product. However, recent studies have shown that these compounds can have negative effects on human health and the environment. Therefore, it is crucial to develop analytical methods to control the amount of these compounds in personal care products to guarantee human health and product quality. This paper presents an HPLC method with electrochemical detection using a gold electrode for the determination of the most used antimicrobial agents in cosmetic products: methylparaben (MP), 4-hydroxybenzoic acid (4-HBA), phenoxyethanol (PE) and methylisothiazolinone (MIT). For this purpose, the electrochemical response of these compounds was evaluated on the gold electrode. The optimal electrochemical detection of MP, 4-HBA; PE and MIT was performed at pH 2 and + 1.50 V (vs Ag/AgCl). Under the optimal separation and detection conditions, limits of detection (LODs) between 10 and 110 μg L− 1 were obtained. These LODs are lower than those previously reported for other HPLC methods with mass spectrometry and diode-array detectors. Cosmetic products with different compositions were successfully analysed with the proposed HPLC method obtaining recoveries between 76 % and 119 %en_US
dc.description.sponsorshipLucía Abad thanks to Universidad Autonoma ´ de Madrid for the predoctoral fellowship (FPI-UAM program). Sergio Lucas-Sanchez ´ acknowledges to Comunidad de Madrid and European Social Fund for the contracts PEJ-2018-AI/BIO-11845 through the Youth Employment Initiative (YEI)en_US
dc.format.extent8 pag.es_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen
dc.publisherElsevieren_US
dc.relation.ispartofMicrochemical Journalen_US
dc.rights© 2022 The Authorsen_US
dc.subject.otherAntimicrobial agentsen_US
dc.subject.otherCosmeticsen_US
dc.subject.otherElectrochemical detectionen_US
dc.subject.otherGold electrodeen_US
dc.subject.otherHPLCen_US
dc.titleHPLC method with electrochemical detection on gold electrode for simultaneous determination of different antimicrobial agents in cosmeticsen_US
dc.typearticleen_US
dc.subject.ecienciaQuímicaes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.microc.2022.107881en_US
dc.identifier.doi10.1016/j.microc.2022.107881
dc.identifier.publicationfirstpage107881-1es_ES
dc.identifier.publicationlastpage107881-8es_ES
dc.identifier.publicationvolume182es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen_US
dc.rights.ccReconocimiento – NoComercial – SinObraDerivadaes_ES
dc.rights.accessRightsopenAccessen_US
dc.facultadUAMFacultad de Cienciases_ES


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