Regulation and functional role of the electron transport chain supercomplexes
Entity
UAM. Departamento de Biología MolecularPublisher
Portland PressDate
2021-10-21Citation
10.1042/BST20210460
Biochemical Society Transactions. 49.6 (2021): 2655-2668
ISSN
0300-5127 (print); 1470-8752 (online)DOI
10.1042/BST20210460Project
Gobierno de España. SAF2017/82886-R; Gobierno de España. RTI2018-099357-B-I00; Gobierno de España. SEV-2015-0505Editor's Version
https://doi.org/10.1042/BST20210460Subjects
Cytochrome c Oxidase; Multienzyme Complex; Reactive Oxygen Metabolite; Succinate Dehydrogenase (Ubiquinone); Supercomplex; Unclassified Drug; Bioenergy; Cell Organelle; Citric Acid Cycle; Cryoelectron Microscopy; Enzyme Activity; Biología y Biomedicina / BiologíaRights
© 2021 The Author(s)Abstract
Mitochondria are one of the most exhaustively investigated organelles in the cell and most attention has been paid to the components of the mitochondrial electron transport chain (ETC) in the last 100 years. The ETC collects electrons from NADH or FADH2 and transfers them through a series of electron carriers within multiprotein respiratory complexes (complex I to IV) to oxygen, therefore generating an electrochemical gradient that can be used by the F1-F0-ATP synthase (also named complex V) in the mitochondrial inner membrane to synthesize ATP. The organization and function of the ETC is a continuous source of surprises. One of the latest is the discovery that the respiratory complexes can assemble to form a variety of larger structures called super-complexes (SCs). This opened an unexpected level of complexity in this well-known and fundamental biological process. This review will focus on the current evidence for the formation of different SCs and will explore how they modulate the ETC organization according to the metabolic state. Since the field is rapidly growing, we also comment on the experimental techniques used to describe these SC and hope that this overview may inspire new technologies that will help to advance the field
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Google Scholar:Cogliati, Sara
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Cabrera Alarcón, José Luis
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Enriquez, Antonio
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