Temperature Dependence of Water Absorption in the Biological Windows and Its Impact on the Performance of Ag2S Luminescent Nanothermometers
10.1002/ppsc.202200100Particle & Particle Systems Characterization (2022): 2200100
ISSN0934-0866 (print); 1521-4117 (online)
Funded byThis work was financed by the Spanish Ministerio de Ciencia e Innovación under project PID2019-106211RB-I00, by the Instituto de Salud Carlos III (PI19/00565), by the Comunidad Autónoma de Madrid (S2017/BMD3867 RENIM-CM) and co-financed by the European structural and investment fund. Additional funding was provided by the European Union Horizon 2020 FETOpen project NanoTBTech (801305), the Fundación para la Investigación Biomédica del Hospital Universitario Ramón y Cajal project IMP21_A4 (2021/0427), and by COST action CA17140. A.B. acknowledges funding support through the TALENTO 2019T1/IND14014 contract (Comunidad Autónoma de Madrid). F.E.M. and L.D.C. acknowledge the financial support received from the project Shape of Water (PTDC/NAN-PRO/3881/2020) through Portuguese funds
ProjectGobierno de España. PI19/00565
SubjectsNanothermometry; Silver sulfide; Temperature dependence; Water absorption; Biología y Biomedicina / Biología
Rights© 2022 The Authors
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.
The application of nanoparticles in the biological context generally requires their dispersion in aqueous media. In this sense, luminescent nanoparticles are an excellent choice for minimally invasive imaging and local temperature sensing (nanothermometry). For these applications, nanoparticles must operate in the physiological temperature range (25–50 °C) but also in the nearinfrared spectral range (750–1800 nm), which comprises the three biological windows of maximal tissue transparency to photons. In this range, water displays several absorption bands that can strongly affect the optical properties of the nanoparticles. Therefore, a full understanding of the temperature dependence of water absorption in biological windows is of paramount importance for applications based on these optical properties. Herein, the absorption spectrum of water in the biological windows over the 25–65 °C temperature range is systematically analyzed, and its temperature dependence considering the coexistence of two states of water is interpreted. Additionally, to illustrate the importance of state-of-the-art applications, the effects of the absorption of water on the emission spectrum of Ag2S nanoparticles, the most sensitive luminescent nanothermometers for in vivo applications to date, are presented. The spectral shape of the nanoparticles’ emission is drastically affected by the water absorption, impacting their thermometric performance
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Google Scholar:Muñoz Ortiz, Tamara - Abiven, Lise - Marin, Riccardo - Hu, Jie - Ortgies, Dirk H. - Benayas Hernández, Antonio - Gazeau, Florence - Castaing, Victor - Viana, Bruno - Chanéac, Corinne - Jaque García, Daniel - Maturi, Fernando E. - Carlos, Luís D. - Martín Rodríguez, Emma - García Solé, José
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Muñoz-Ortiz, Tamara; Hu, Jie; Ortgies, Dirk H.; Shrikhande, Shreya; Zamora-Perez, Paula; Granado, Miriam; González-Hedström, Daniel; de la Fuente-Fernández, María; García-Villalón, Ángel Luis; Andrés-Delgado, Laura; Martín Rodríguez, Emma; Aguilar, Río; Alfonso, Fernando; García Solé, José; Rivera Gil, Pilar; Jaque, Daniel; Rivero, Fernando