Electron holes in G-Quadruplexes: The role of adenine ending groups
EntityUAM. Departamento de Química
10.3390/ijms222413436International Journal of Molecular Sciences 22.24 (2021): 13436
ISSN1661-6596 (print); 1422-0067 (online)
SubjectsAdenine; Cation; Deoxyguanosine Phosphate; Guanine; Guanine Quadruplex; Absorption Spectroscopy; Anisotropy; Deprotonation; DNA Structure; Electron; Oxidative Stress; Química
Rights© 2021 by the authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
The study deals with four-stranded DNA structures (G-Quadruplexes), known to undergo ionization upon direct absorption of low-energy UV photons. Combining quantum chemistry calculations and time-resolved absorption spectroscopy with 266 nm excitation, it focuses on the electron holes generated in tetramolecular systems with adenine groups at the ends. Our computations show that the electron hole is placed in a single guanine site, whose location depends on the position of the adenines at the 3′ or 5′ ends. This position also affects significantly the electronic absorption spectrum of (G+ )• radical cations. Their decay is highly anisotropic, composed of a fast process (<2 µs), followed by a slower one occurring in ~20 µs. On the one hand, they undergo deprotonation to (G-H2)• radicals and, on the other, they give rise to a reaction product absorbing in the 300–500 nm spectral domain
Google Scholar:Balanikas, Evangelos - Martínez Fernández, Lara - Baldacchino, Gérard - Markovitsi, Dimitra
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