Natural extracts to augment energy expenditure as a complementary approach to tackle obesity and associated metabolic alterations
EntityUAM. Departamento de Química Física Aplicada
10.3390/biom11030412Biomolecules 11.3 (2021): 412
ProjectComunidad de Madrid. IND2017/BIO-7826; Gobierno de España. PID2019-110183RB-C21; Comunidad de Madrid. S2018/BAA-4343/ALIBIRD2020-CM
SubjectsAdipocytes; Cell Differentiation; Energy Metabolism; Gene Expression Regulation; Mitochondria; Myoblasts; Oxidative Phosphorylation; Plant Extracts; Thermogenesis; Lipids; Química
Rights© 2021 by the authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Obesity is the epidemic of the 21st century. In developing countries, the prevalence of obesity continues to rise, and obesity is occurring at younger ages. Obesity and associated metabolic stress disrupt the whole‐body physiology. Adipocytes are critical components of the systemic metabolic control, functioning as an endocrine organ. The enlarged adipocytes during obesity recruit macrophages promoting chronic inflammation and insulin resistance. Together with the genetic susceptibility (single nucleotide polymorphisms, SNP) and metabolic alterations at the molecular level, it has been highlighted that key modifiable risk factors, such as those related to lifestyle, contribute to the development of obesity. In this scenario, urgent therapeutic options are needed, including not only pharmacotherapy but also nutrients, bioactive compounds, and natural extracts to reverse the metabolic alterations associated with obesity. Herein, we first summarize the main tar-getable processes to tackle obesity, including activation of thermogenesis in brown adipose tissue (BAT) and in white adipose tissue (WAT‐browning), and the promotion of energy expenditure and/or fatty acid oxidation (FAO) in muscles. Then, we perform a screening of 20 natural extracts (EFSA approved) to determine their potential in the activation of FAO and/or thermogenesis, as well as the increase in respiratory capacity. By means of innovative technologies, such as the study of their effects on cell bioenergetics (Seahorse bioanalyzer), we end up with the selection of four extracts with potential application to ameliorate the deleterious effects of obesity and the chronic associated inflammation
Google Scholar:Reguero, Marina - Gómez de Cedrón, Marta - Reglero Rada, Guillermo J. - Quintela, José Carlos - Ramírez de Molina, Ana
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