Organoids and colorectal cancer
Entidad
UAM. Departamento de Cirugía; UAM. Departamento de MedicinaFecha de edición
2021-05-28Cita
10.3390/cancers13112657
Cancers 13.11 (2021): 2657
ISSN
2072-6694DOI
10.3390/cancers13112657Financiado por
The work in the authors’ laboratory is funded by the Agencia Estatal de Investigación (PID2019‐104867RB‐I00/AEI/10.13039/501100011033), the Ministerio de Ciencia e Innovación (SAF2017‐90604‐REDT/NuRCaMeIn), and the Instituto de Salud Carlos III—Fondo Europeo de Desarrollo Regional (CIBERONC/CB16/12/00273, CIBERONC/CB16/12/00398 and ICI20/00057).Proyecto
Gobierno de España. PID2019-104867RB-I00/AEI/10.13039/501100011033; Gobierno de España. SAF2017‐90604‐REDT/NuRCaMeIn; Gobierno de España. CIBERONC/CB16/12/00273; Gobierno de España. CIBERONC/CB16/12/00398; Gobierno de España. ICI20/00057Materias
organoids; patient-derived organoid/PDO; patient-derived tumor organoid/PDTO; colon; colorectal; cancer; MedicinaDerechos
© 2021 by the authors.Resumen
Organoids were first established as a three‐dimensional cell culture system from mouse small intestine. Subsequent development has made organoids a key system to study many human physiological and pathological processes that affect a variety of tissues and organs. In particular, organoids are becoming very useful tools to dissect colorectal cancer (CRC) by allowing the circumvention of classical problems and limitations, such as the impossibility of long‐term culture of normal intestinal epithelial cells and the lack of good animal models for CRC. In this review, we describe the features and current knowledge of intestinal organoids and how they are largely contributing to our better understanding of intestinal cell biology and CRC genetics. Moreover, recent data show that organoids are appropriate systems for antitumoral drug testing and for the personalized treatment of CRC patients.
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Google Scholar:Barbáchano, Antonio
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Fernández‐barral, Asunción
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Bustamante‐madrid, Pilar
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Prieto Nieto, María Isabel
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Rodríguez Salas, Nuria
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Larriba, María Jesús
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Muñoz, Alberto
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