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dc.contributor.authorBarbáchano, Antonio
dc.contributor.authorFernández‐barral, Asunción
dc.contributor.authorBustamante‐madrid, Pilar
dc.contributor.authorPrieto Nieto, María Isabel 
dc.contributor.authorRodríguez Salas, Nuria 
dc.contributor.authorLarriba, María Jesús
dc.contributor.authorMuñoz, Alberto
dc.contributor.otherUAM. Departamento de Cirugíaes_ES
dc.contributor.otherUAM. Departamento de Medicinaes_ES
dc.date.accessioned2022-10-19T09:15:45Z
dc.date.available2022-10-19T09:15:45Z
dc.date.issued2021-05-28
dc.identifier.citationCancers 13.11 (2021): 2657en_US
dc.identifier.issn2072-6694es_ES
dc.identifier.urihttp://hdl.handle.net/10486/704577
dc.description.abstractOrganoids were first established as a three‐dimensional cell culture system from mouse small intestine. Subsequent development has made organoids a key system to study many human physiological and pathological processes that affect a variety of tissues and organs. In particular, organoids are becoming very useful tools to dissect colorectal cancer (CRC) by allowing the circumvention of classical problems and limitations, such as the impossibility of long‐term culture of normal intestinal epithelial cells and the lack of good animal models for CRC. In this review, we describe the features and current knowledge of intestinal organoids and how they are largely contributing to our better understanding of intestinal cell biology and CRC genetics. Moreover, recent data show that organoids are appropriate systems for antitumoral drug testing and for the personalized treatment of CRC patients.en_US
dc.description.sponsorshipThe work in the authors’ laboratory is funded by the Agencia Estatal de Investigación (PID2019‐104867RB‐I00/AEI/10.13039/501100011033), the Ministerio de Ciencia e Innovación (SAF2017‐90604‐REDT/NuRCaMeIn), and the Instituto de Salud Carlos III—Fondo Europeo de Desarrollo Regional (CIBERONC/CB16/12/00273, CIBERONC/CB16/12/00398 and ICI20/00057).en_US
dc.format.extent24 pag.es_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen_US
dc.relation.ispartofCancersen_US
dc.rights© 2021 by the authors.en_US
dc.subject.otherorganoidsen_US
dc.subject.otherpatient-derived organoid/PDOen_US
dc.subject.otherpatient-derived tumor organoid/PDTOen_US
dc.subject.othercolonen_US
dc.subject.othercolorectalen_US
dc.subject.othercanceren_US
dc.titleOrganoids and colorectal canceren_US
dc.typereviewen_US
dc.subject.ecienciaMedicinaes_ES
dc.identifier.doi10.3390/cancers13112657en_US
dc.identifier.publicationfirstpage2657-1es_ES
dc.identifier.publicationissue11es_ES
dc.identifier.publicationlastpage2657-24es_ES
dc.identifier.publicationvolume13es_ES
dc.relation.projectIDGobierno de España. PID2019-104867RB-I00/AEI/10.13039/501100011033es_ES
dc.relation.projectIDGobierno de España. SAF2017‐90604‐REDT/NuRCaMeInes_ES
dc.relation.projectIDGobierno de España. CIBERONC/CB16/12/00273es_ES
dc.relation.projectIDGobierno de España. CIBERONC/CB16/12/00398es_ES
dc.relation.projectIDGobierno de España. ICI20/00057es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen_US
dc.rights.accessRightsopenAccessen_US
dc.facultadUAMFacultad de Medicinaes_ES
dc.institutoUAMInstituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)es_ES


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