Long-term nightshift work and breast cancer risk: An updated systematic review and meta-analysis with special attention to menopausal status and to recent nightshift work
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y MicrobiologíaPublisher
Basel: MDPIDate
2021-12-26Citation
10.3390/cancers13235952
Cancers. 13.23 (2021): 5952
ISSN
2072-6694DOI
10.3390/cancers13235952Funded by
This research received no external funding.Editor's Version
https://doi.org/10.3390/cancers13235952Subjects
nightshift work; breast cancer; recent exposure; meta-analysis; menopausal status; occupational exposure; retirement age; MedicinaRights
© 2021 by the authors.Abstract
This systematic review discusses long-term NSW and female BC risk, with special attention to differences between pre-and postmenopausal BC, to test the association with recent NSW. The review follows PRISMA guidelines (Prospero registry: CRD42018102515). We searched PubMed, Embase, and WOS for case–control, nested case–control, and cohort studies addressing long-term NSW (≥15 years) as risk exposure and female BC as outcome until 31 December 2020. Risk of bias was evaluated with the Newcastle–Ottawa scale. Eighteen studies were finally in-cluded (eight cohorts; five nested case–control; five case–control). We performed meta-analyses on long-term NSW and BC risk; overall and by menopausal status; a subanalysis on recent long-term NSW, based on studies involving predominantly women below retirement age; and a dose– response meta-analysis on NSW duration. The pooled estimate for long-term NSW and BC was 1.13 (95%CI = 1.01–1.27; 18 studies, I2 = 56.8%, p = 0.002). BC risk increased 4.7% per 10 years of NSW (95%CI = 0.94–1.09; 16 studies, I2 = 33.4%, p = 0.008). The pooled estimate for premenopausal BC was 1.27 (95%CI = 0.96–1.68; six studies, I2 = 32.0%, p = 0.196) and for postmenopausal BC 1.05 (95%CI = 0.90–1.24, I2 = 52.4%; seven studies, p = 0.050). For recent long-term exposure, the pooled estimate was 1.23 (95%CI = 1.06–1.42; 15 studies; I2 = 48.4%, p = 0.018). Our results indicate that long-term NSW increases the risk for BC and that menopausal status and time since exposure might be relevant.
Files in this item
Google Scholar:Schwarz, Christine
-
Pedraza-Flechas, Ana María
-
Pastor-Barriuso, Roberto
-
Lope, Virginia
-
de Larrea, Nerea Fernández
-
Jiménez-Moleón, José Juan
-
Pollán Santamaría, Marina Anunciación
-
Pérez Gómez, Beatriz
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Serum phospholipid fatty acids levels, anthropometric variables and adiposity in spanish premenopausal women
Pozo, María del Pilar del; Lope, Virginia; Criado-Navarro, Inmaculada; Pastor-Barriuso, Roberto; Fernández de Larrea, Nerea; Ruiz, Emma; Castelló, Adela; Lucas, Pilar; Sierra, Ángeles; Romieu, Isabelle; Chajès, Véronique; Priego-Capote, Feliciano; Pérez-Gómez, Beatriz; Pollán Santamaría, Marina Anunciación
2020-06-25 -
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain
Fernández de Larrea-Baz, Nerea; Michel, Angelika; Romero, Beatriz; Pérez-Gómez, Beatriz; Moreno, Víctor; Martín, Vicente; Dierssen-Sotos, Trinidad; Jiménez-Moleón, José J.; Castilla, Jesús; Tardón, Adonina; Ruiz, Irune; Peiró, Rosana; Tejada, Antonio; Chirlaque, María D.; Butt, Julia A.; Olmedo-Requena, Rocío; Gómez-Acebo, Inés; Linares, Pedro; Boldo, Elena; Castells, Antoni; Pawlita, Michael; Castaño-Vinyals, Gemma; Kogevinas, Manolis; Sanjosé, Silvia de; Pollán Santamaría, Marina Anunciación; Campo, Rosa del; Waterboer, Tim; Aragonés, Nuria
2017-05-29