Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
Genome-wide phenotypic RNAi screen in the Drosophila wing: Global parameters
Entidad
UAM. Departamento de Biología MolecularEditor
Oxford University Press on behalf of Genetics Society of AmericaFecha de edición
2021-12-01Cita
10.1093/g3journal/jkab351
G3-Genes Genomes Genetics 11.12 (2021): jkab351
ISSN
2160-1836DOI
10.1093/g3journal/jkab351Proyecto
Gobierno de España. PGC2018-094476-B-I00Versión del editor
https://doi.org/10.1093/g3journal/jkab351Materias
Animals; Drosophila; Drosophila Melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Phenotype; RNA Interference; Wings, Animal; Biología y Biomedicina / BiologíaDerechos
© 2021 The AuthorsResumen
We have screened a collection of UAS-RNAi lines targeting 10,920 Drosophila protein-coding genes for phenotypes in the adult wing. We identified 3653 genes (33%) whose knockdown causes either larval/pupal lethality or a mutant phenotype affecting the formation of a normal wing. The most frequent phenotypes consist of changes in wing size, vein differentiation, and patterning, defects in the wing margin and in the apposition of the dorsal and ventral wing surfaces. We also defined 16 functional categories encompassing the most relevant aspect of each protein function and assigned each Drosophila gene to one of these functional groups. This allowed us to identify which mutant phenotypes are enriched within each functional group. Finally, we used previously published gene expression datasets to determine which genes are or are not expressed in the wing disc. Integrating expression, phenotypic and molecular information offers considerable precision to identify the relevant genes affecting wing formation and the biological processes regulated by them
Lista de ficheros
Google Scholar:López-Varea, Ana
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Ostalé, Cristina M.
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Vega Cuesta, Patricia
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Ruiz Gómez, Ana
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Organista, Maria F.
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Martín, Mercedes
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Hevia, Covadonga F.
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Molnar, Cristina
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De Celis, Jesús
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Culí, Joaquín
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Esteban, Nuria
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De Celis, Jose F.
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