Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
Systematic characterization of cell competition between cancer cells and hepatocytes
Title (trans.)
Caracterización sistemática de Competición Celular entre células tumorales malignas y hepatocitosAuthor
Spinazzola, AndreaEntity
UAM. Departamento de BiologíaDate
2022-09-26Subjects
Células cancerosas; Metástasis; Biología y Biomedicina / BiologíaNote
Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Biología. Fecha de Lectura: 26-09-2022Esta tesis tiene embargado el acceso al texto completo hasta el 26-03-2024
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Abstract
Competitive interactions between tumor cells and surrounding healthy cells are constantly present during the progression of a solid tumor, and their outcome has been proposed to affect the growth pattern and clinical behavior. Previous studies have described various mechanistic and molecular aspects that characterize this process, overall indicating that cancer cells behave as supercompetitors, which eliminate neighboring healthy cells to gain vital space for growth and infiltrate the tissue. Nevertheless, there is a lack of systematic characterization of these competitive interactions, particularly in the context of mammalian tumors. In this thesis, I study the competition between numerous cancer cell lines and hepatocytes, and provide a broad characterization of this process in different relevant scenarios, including cells growing in vitro in 2D and 3D, and liver metastases. Results show that in vitro, only a subset of cancer cell lines are coherently strong or moderate competitors, while the remaining behave as poor competitors. This competitive proficiency predicts the phenotype of liver metastases, with the three strongest competitors generating aggressive metastases with an infiltrative growth pattern. On the contrary, four out of five of the remaining cell lines resulted in a milder disease which often displayed expansile growth. Finally, the competitive phenotype can vary depending on the experimental growth system that is employed
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