Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
EntityUAM. Departamento de Biología Molecular
10.1002/bies.202200136BioEssays (2022): e2200064
ISSN0265-9247 (print); 1521-1878 (electronic)
SubjectsAcid digestion; Eukaryogenesis; Mitochondriogenesis; Phagocytosis; Proton gradient; Biología y Biomedicina / Biología
Rights© 2022 The Authors
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
The initial relationships between organisms leading to endosymbiosis and the first eukaryote are currently a topic of hot debate. Here, I present a theory that offers a gradual scenario in which the origins of phagocytosis and mitochondria are intertwined in such a way that the evolution of one would not be possible without the other. In this scenario, the premitochondrial bacterial symbiont became initially associated with a protophagocytic host on the basis of cooperation to kill prey with symbiontproduced toxins and reactive oxygen species (ROS). Subsequently, the cooperation was focused on the digestion stage, through the acidification of the protophagocytic cavities via exportation of protons produced by the aerobic respiration of the symbiont. The host gained an improved phagocytic capacity and the symbiont received organic compounds from prey. As the host gradually lost its membrane energetics to develop lysosomal digestion, respiration was centralized in the premitochondrial symbiont for energy production for the consortium
Google Scholar:Mencía Caballero, Mario
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