Photothermal effect by 808-nm laser irradiation of melanin: A proof-of-concept study of photothermal therapy using b16-f10 melanotic melanoma growing in BALB/c mice
EntityUAM. Departamento de Física Teórica
PublisherOptica Publishing Group
10.1364/BOE.10.002932Biomedical Optics Express 10.6 (2019): 2932-2941
SubjectsBiología y Biomedicina / Biología
Rights© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
The photothermal effect is undergoing great interest due to advances in new photosensitizing materials and better-suited light sources, but studies are frequently hampered by the need to employ exogenous photothermal agents and expensive irradiation devices. Here we present a simple strategy based on direct NIR irradiation of the melanin pigment with a commercial 808-nm laser pointer. Proof-of-concept studies showed efficient photothermal effects on melanin in vitro and in vivo. After NIR irradiation, BALB/c mice bearing B16-F10 melanotic melanoma tumors revealed severe histopathological damage and massive necrosis in melanin-containing tumor tissue, while surrounding healthy tissues showed no damage. Therefore, the feasibility of this approach may allow implementing direct procedures for photothermal therapy of pigmented tumors
Google Scholar:Colombo, Lucas L. - Vanzulli, Silvia I. - Blázquezcastro, Alfonso - Terrero, Clara Sanchez - Stockert, Juan C.
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