DNA damage and repair in human reproductive cells
EntityUAM. Departamento de Biología
PublisherMDPI [Commercial Publisher]
10.3390/ijms20010031International Journal of Molecular Sciences 20.1 (2019): 31
ISSN1661-6596 (print); 1422-0067 (electronic)
ProjectGobierno de España. BFU-2013-44290-R
Subjectsspermatozoon; oocyte; DNA damage; DNA repair; protamine; genetics; infertility; Biología y Biomedicina / Biología
Rights© 2018 by the authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
The fundamental underlying paradigm of sexual reproduction is the production of male and female gametes of sufficient genetic difference and quality that, following syngamy, they result in embryos with genomic potential to allow for future adaptive change and the ability to respond to selective pressure. The fusion of dissimilar gametes resulting in the formation of a normal and viable embryo is known as anisogamy, and is concomitant with precise structural, physiological, and molecular control of gamete function for species survival. However, along the reproductive life cycle of all organisms, both male and female gametes can be exposed to an array of “stressors” that may adversely affect the composition and biological integrity of their proteins, lipids and nucleic acids, that may consequently compromise their capacity to produce normal embryos. The aim of this review is to highlight gamete genome organization, differences in the chronology of gamete production between the male and female, the inherent DNA protective mechanisms in these reproductive cells, the aetiology of DNA damage in germ cells, and the remarkable DNA repair mechanisms, pre- and post-syngamy, that function to maintain genome integrity
Google Scholar:García Rodríguez, Anaís - Gosalbez Berenguer, José Jaime - Agarwal, Ashok - Roy Barcelona, Rosa - Johnston, Stephen
This item appears in the following Collection(s)
Showing items related by title, author, creator and subject.