Site-Selective functionalization of C(sp3 ) Vicinal Boronic Esters
EntityUAM. Departamento de Química Orgánica
PublisherAmerican Chemical Society
10.1021/acscatal.2c02857ACS Catalysis 12.17 (2022): 10603–10620
Funded byThis work was supported by the MICINN (PID2019- 107380GB-I00)
Subjects1,2-shift; Boro-Wittig reaction; Boron; Boronate allylation; Site-selective functionalization; Suzuki-Miyaura cross-coupling; Vicinal boronates; Química
Rights© 2022 American Chemical Society
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Selective functionalization of the C−B bond in 1,2- bis(boronate) esters has emerged as a powerful tool to prepare 1,2- difunctionalized compounds with stereocontrol. Selective Suzuki crosscoupling, oxidation, amination, and homologation reactions serve as platforms to prepare a wide variety of compounds from a common intermediate. The exquisite selectivity offered and their easy preparation from feedstock material using a myriad of catalytic transformations make them attractive building blocks for the preparation of complex molecules. In this Perspective, we summarize the examples of selective C−B bond functionalization of vicinal bis(boronates), attending to the nature of the C−B bond functionalization
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