T Lymphocyte and CAR-T Cell-Derived Extracellular Vesicles and Their Applications in Cancer Therapy
EntityUAM. Departamento de Bioquímica
10.3390/cells11050790Cells 11.5 (2022): 790
Funded byThis publication is part of the Grant PID2020-114148RB-I00 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”, by the “European Union”
ProjectGobierno de España. PID2020-114148RB-I00; Gobierno de España. MCIN/AEI/10.13039/501100011033
SubjectsCAR T lymphocytes; Cell death; Cytotoxic activity; Exosomes; Immune synapse; Multivesicular bodies; Secretory granules; T lymphocytes; Medicina
Rights© 2022 by the authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Extracellular vesicles (EV) are a very diverse group of cell-derived vesicles released by almost all kind of living cells. EV are involved in intercellular exchange, both nearby and systemically, since they induce signals and transmit their cargo (proteins, lipids, miRNAs) to other cells, which subsequently trigger a wide variety of biological responses in the target cells. However, cell surface receptor-induced EV release is limited to cells from the immune system, including T lymphocytes. T cell receptor activation of T lymphocytes induces secretion of EV containing T cell receptors for antigen and several bioactive molecules, including proapoptotic proteins. These EV are specific for antigen-bearing cells, which make them ideal candidates for a cell-free, EV-dependent cancer therapy. In this review we examine the generation of EV by T lymphocytes and CAR-T cells and some potential therapeutic approaches of these EV
Files in this item
This item appears in the following Collection(s)
Showing items related by title, author, creator and subject.