Show simple item record

dc.contributor.authorVillalba Abarca, Marisol
dc.contributor.authorSilván Jiménez, José Manuel
dc.contributor.authorAlarcón Cavero, Teresa 
dc.contributor.authorVillanueva Bermejo, David 
dc.contributor.authorJaime de Pablo, Laura 
dc.contributor.authorSantoyo Díez, Susana 
dc.contributor.authorMartínez-Rodríguez, Adolfo J.
dc.contributor.otherUAM. Departamento de Química Física Aplicadaes_ES
dc.date.accessioned2023-02-16T12:05:55Z
dc.date.available2023-02-16T12:05:55Z
dc.date.issued2022-09-20
dc.identifier.citationAntioxidants 11.10 (2022): 1849es_ES
dc.identifier.issn2076-3921 (online)es_ES
dc.identifier.urihttp://hdl.handle.net/10486/706372
dc.description.abstractThe main objective of this work is to evaluate the potential utility of an Achillea millefolium extract (yarrow extract, YE) in the control of H. pylori infection. The supercritical anti-solvent fractionation (SAF) process of YE allowed the obtaining of two different fractions: yarrow’s precipitated fraction (YPF), enriched in most polar phenolic compounds (luteolin-7-O-glucoside, luteolin, and 3,5-dicaffeoylquinic acid), and yarrow’s separator fraction (YSF), enriched in monoterpenes and sesquiterpenes, mainly containing camphor, artemisia ketone, and borneol. YE was effective in reducing reactive oxygen species (ROS) production in human gastric AGS cells by 16% to 29%, depending on the H. pylori strain. YPF had the highest inhibitory activity (38–40%) for ROS production. YE modulated the inflammatory response in AGS gastric cells, decreasing IL-8 production by 53% to 64%. This IL-8 inhibition also showed a strain-dependent character. YPF and YSF exhibited similar behavior, reducing IL-8 production, suggesting that both phenolic compounds and essential oils could contribute to IL-8 inhibition. YSF showed the highest antibacterial activity against H. pylori (6.3–7.1 log CFU reduction, depending on the strain) and lower MIC (0.08 mg/mL). Results obtained have shown that YE and SAF fractions (YPF and YSF) were effective as antioxidant, anti-inflammatory, and antibacterial agents regardless of the H. pylori strain characteristicses_ES
dc.format.extent15 pag.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.ispartofAntioxidantses_ES
dc.rights© 2022 by the authorses_ES
dc.subject.otherAchilleaes_ES
dc.subject.otherCineolees_ES
dc.subject.otherExtractes_ES
dc.titleAntioxidant, anti-Inflammatory, and antibacterial properties of an Achillea millefolium L. extract and Its fractions obtained by supercritical anti-solvent fractionation against Helicobacter pylories_ES
dc.typearticlees_ES
dc.subject.ecienciaQuímicaes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/antiox11101849es_ES
dc.identifier.doi10.3390/antiox11101849es_ES
dc.identifier.publicationfirstpage1849-1es_ES
dc.identifier.publicationissue10es_ES
dc.identifier.publicationlastpage1849-15es_ES
dc.identifier.publicationvolume11es_ES
dc.relation.projectIDGobierno de España. AGL2017-89566-Res_ES
dc.relation.projectIDComunidad de Madrid. S2018/BAA-4343/ALIBIRD2020-CMes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersiones_ES
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccesses_ES
dc.facultadUAMFacultad de Cienciases_ES
dc.institutoUAMInstituto de Investigación en Ciencias de la Alimentación (CIAL)es_ES


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record