A coarse-grained approach to model the dynamics of the actomyosin cortex
Entidad
UAM. Departamento de Biología Molecular; UAM. Departamento de Física de la Materia Condensada; UAM. Departamento de Física Teórica de la Materia CondensadaEditor
BMCFecha de edición
2022-04-22Cita
10.1186/s12915-022-01279-2
BMC Biology 20.1 (2022): 90
ISSN
1741-7007 (online)DOI
10.1186/s12915-022-01279-2Proyecto
Gobierno de España. RTI2018-096953-B-I00; Gobierno de España. CEX2018-000805-M; Gobierno de España. BFU2014-53299-PVersión del editor
https://doi.org/10.1186/s12915-022-01279-2Materias
Actin; Myosin; Myosin Adenosine Triphosphatase; Biología y Biomedicina / Biología; FísicaDerechos
© The Author(s) 2022Resumen
Background: The dynamics of the actomyosin machinery is at the core of many important biological processes. Several relevant cellular responses such as the rhythmic compression of the cell cortex are governed, at a mesoscopic level, by the nonlinear interaction between actin monomers, actin crosslinkers, and myosin motors. Coarse-grained models are an optimal tool to study actomyosin systems, since they can include processes that occur at long time and space scales, while maintaining the most relevant features of the molecular interactions. Results: Here, we present a coarse-grained model of a two-dimensional actomyosin cortex, adjacent to a three-dimensional cytoplasm. Our simplified model incorporates only well-characterized interactions between actin monomers, actin crosslinkers and myosin, and it is able to reproduce many of the most important aspects of actin filament and actomyosin network formation, such as dynamics of polymerization and depolymerization, treadmilling, network formation, and the autonomous oscillatory dynamics of actomyosin. Conclusions: We believe that the present model can be used to study the in vivo response of actomyosin networks to changes in key parameters of the system, such as alterations in the attachment of actin filaments to the cell cortex
Lista de ficheros
Google Scholar:Hernandez-del-Valle, Miguel
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Valencia-Expósito, Andrea
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López-Izquierdo, Antonio
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Casanova Ferrer, Pau
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Tarazona Lafarga, Pedro José
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Martín-Bermudo, Martín-Bermudo
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Miguez Gómez, David
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