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Photophysical Characterization of Isoguanine in a Prebiotic-Like Environment
dc.contributor.author | Ortín Fernández, Francisco Javier | |
dc.contributor.author | Caldero Rodríguez, Naishka E. | |
dc.contributor.author | Crespo Hernández, Carlos E. | |
dc.contributor.author | Martínez Fernández, Lara | |
dc.contributor.author | Corral Pérez, Inés | |
dc.contributor.other | UAM. Departamento de Química | es_ES |
dc.date.accessioned | 2023-03-13T09:45:29Z | |
dc.date.available | 2023-03-13T09:45:29Z | |
dc.date.issued | 2023-01-24 | |
dc.identifier.citation | Chemistry A European Journal (2023): e202203580 | en_US |
dc.identifier.issn | 0947-6539 (print) | en_US |
dc.identifier.issn | 1521-3765 (online) | en_US |
dc.identifier.uri | http://hdl.handle.net/10486/706608 | |
dc.description.abstract | It is intriguing how a mixture of organic molecules survived the prebiotic UV fluxes and evolved into the actual genetic building blocks. Scientists are trying to shed light on this issue by synthesizing nucleic acid monomers and their analogues under prebiotic Era-like conditions and by exploring their excited state dynamics. To further add to this important body of knowledge, this study discloses new insights into the photophysical properties of protonated isoguanine, an isomorph of guanine, using steady-state and femtosecond broadband transient absorption spectroscopies, and quantum mechanical calculations. Protonated isoguanine decays in ultrafast time scales following 292 nm excitation, consistently with the barrierless paths connecting the bright S1 (ππ*) state with different internal conversion funnels. Complementary calculations for neutral isoguanine predict similar photophysical properties. These results demonstrate that protonated isoguanine can be considered photostable in contrast to protonated guanine, which exhibits 40-fold longer excited state lifetimes | en_US |
dc.description.sponsorship | The authors acknowledge funding from the National Science Foundation (Grant No. CHE-1800052), the Ramón y Cajal Program (Grant: RYC-2016-20489) and the Ministerio de Ciencia, Innovación y Universidades (PGC2018-094644-B-C21, PID2021- 125207NB-C31 and PRE2019-090448 projects). L. M. F. thanks the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with Universidad Autónoma de Madrid in the line Support to Young Researchers, in the context of the V PRICIT (Regional Programme of Research and Technological Innovation) (SI3/PJI/2021-00331) | en_US |
dc.format.extent | 9 pag. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | en |
dc.publisher | Wiley | en_US |
dc.relation.ispartof | Chemistry A European Journal | en_US |
dc.rights | © 2023 The Authors | en_US |
dc.subject.other | Ab initio calculations | en_US |
dc.subject.other | Excited state dynamics | en_US |
dc.subject.other | Modified nucleobases | en_US |
dc.subject.other | Nucleobase ancestors | en_US |
dc.subject.other | Prebiotic chemistry | en_US |
dc.title | Photophysical Characterization of Isoguanine in a Prebiotic-Like Environment | en_US |
dc.type | article | en_US |
dc.subject.eciencia | Química | es_ES |
dc.relation.publisherversion | https://doi.org/10.1002/chem.202203580 | en_US |
dc.identifier.publicationfirstpage | e202203580-1 | en_US |
dc.identifier.publicationlastpage | e202203580-9 | en_US |
dc.relation.projectID | Gobierno de España. PID2021-125207NB-C31 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en_US |
dc.rights.cc | Reconocimiento – NoComercial – SinObraDerivada | es_ES |
dc.rights.accessRights | openAccess | en_US |
dc.facultadUAM | Facultad de Ciencias | es_ES |