Eosin Y-functionalized upconverting nanoparticles: nanophotosensitizers and deep tissue bioimaging agents for simultaneous therapeutic and diagnostic applications
Entity
UAM. Departamento de Biología; UAM. Departamento de Física Aplicada; UAM. Departamento de Física de Materiales; UAM. Departamento de Química OrgánicaPublisher
MDPIDate
2022-12-23Citation
10.3390/cancers15010102
Cancers 15.1 (2023): 102
ISSN
2072-6694 (online)DOI
10.3390/cancers15010102Project
Gobierno de España. MAT2016-75362-C3-1-R; Gobierno de España. PID2019-106211RB-I00; Gobierno de España. CTQ2017-85454-C2-2-P; Gobierno de España. PID2020-113059GB-C22; info:eu-repo/grantAgreement/EC/H2020/801305/EU//NanoTBTechEditor's Version
https://doi.org/10.3390/cancers15010102Subjects
ROS; Photodynamic Therapy; Upconversion Nanoparticles; Infrared Imaging; Eosin Y; Biología y Biomedicina / Biología; Física; QuímicaRights
© 2022 by the authors. Licensee MDPI, Basel, SwitzerlandAbstract
Functionalized upconverting nanoparticles (UCNPs) are promising theragnostic nanomaterials for simultaneous therapeutic and diagnostic purposes. We present two types of non-toxic eosin Y (EY) nanoconjugates derived from UCNPs as novel nanophotosensitizers (nano-PS) and deep-tissue bioimaging agents employing light at 800 nm. This excitation wavelength ensures minimum cell damage, since the absorption of water is negligible, and increases tissue penetration, enhancing the specificity of the photodynamic treatment (PDT). These UCNPs are uniquely qualified to fulfil three important roles: as nanocarriers, as energy-transfer materials, and as contrast agents. First, the UCNPs enable the transport of EY across the cell membrane of living HeLa cells that would not be possible otherwise. This cellular internalization facilitates the use of such EY-functionalized UCNPs as nano-PS and allows the generation of reactive oxygen species (ROS) under 800 nm light inside the cell. This becomes possible due to the upconversion and energy transfer processes within the UCNPs, circumventing the excitation of EY by green light, which is incompatible with deep tissue applications. Moreover, the functionalized UCNPs present deep tissue NIR-II fluorescence under 808 nm excitation, thus demonstrating their potential as bioimaging agents in the NIR-II biological window
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Google Scholar:López-Peña, Gabriel
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Simón-Fuente, Silvia
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Ortgies, Dirk H.
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Moliné, María Ángeles
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Martín Rodríguez, Emma
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Sanz Rodríguez, Francisco
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Ribagorda Lobera, María
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