A small change with a twist ending: a single residue in EGF-CFC drives bilaterian asymmetry
Entity
UAM. Departamento de BiologíaPublisher
Oxford University PressDate
2023-02-03Citation
10.1093/molbev/msac270
Molecular biology and evolution 40.2 (2023): msac270
ISSN
0737-4038 (print); 1537-1719 (online)DOI
10.1093/molbev/msac270Project
Gobierno de España. CGL2011-29916; Gobierno de España. PID2019-104812GB-I00Editor's Version
https://doi.org/10.1093/molbev/msac270Subjects
EGF-CFC; EvoDevo; Nodal; Spiralia; zebrafish; Crepidula Fornicata; Cripto; Gene Expression Pattern; Left-Right Asymmetry; Biología y Biomedicina / BiologíaNote
This is a pre-copyedited, author-produced PDF of an article accepted for publication in Molecular biology and evolution following peer review. The version of record Molecular biology and evolution 40.2 (2023): msac270 is available online at: https://academic.oup.com/search-results?page=1&q=10.1093%2Fmolbev%2Fmsac270&fl_SiteID=191&SearchSourceType=1&allJournals=1Rights
© The Author(s) 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and EvolutionAbstract
Asymmetries are essential for proper organization and function of organ systems. Genetic studies in bilaterians have shown signaling through the Nodal/Smad2 pathway plays a key, conserved role in the establishment of body asymmetries. Although the main molecular players in the network for the establishment of left-right asymmetry (LRA) have been deeply described in deuterostomes, little is known about the regulation of Nodal signaling in spiralians. Here, we identified orthologs of the egf-cfc gene, a master regulator of the Nodal pathway in vertebrates, in several invertebrate species, which includes the first evidence of its presence in non-deuterostomes. Our functional experiments indicate that despite being present, egf-cfc does not play a role in the establishment of LRA in gastropods. However, experiments in zebrafish suggest that a single amino acid mutation in the egf-cfc gene in at least the common ancestor of chordates was the necessary step to induce a gain of function in LRA regulation. This study shows that the egf-cfc gene likely appeared in the ancestors of deuterostomes and "protostomes", before being adopted as a mechanism to regulate the Nodal pathway and the establishment of LRA in some lineages of deuterostomes
Files in this item
Google Scholar:Truchado-García, Marta
-
Perry, Kimberly J.
-
Cavodeassi, Florencia
-
Kenny, Nathan J.
-
Henry, Jonathan Q.
-
Grande Pardo, María Cristina
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease
Escott-Price, Valentina; Bellenguez, Céline; Wang, Lisan; Choi, Seunghoan; Harold, Denise H.; Jones, Lesley A.; Holmans, Peter A.; Gerrish, Amy; Vedernikov, Alexey; Richards, Alexander L.; Destefano, Anita L.; Lambert, Jean Charles; Ibrahim-Verbaas, Carla A.; Naj, Adam C.; Sims, Rebecca J A; Jun, Gyungah; Bis, Joshua C M; Beecham, Gary W.; Grenier-Boley, Benjamin; Russo, Giancarlo Carlo; Thornton-Wells, Tricia A.; Denning, Nicola; Smith, Albert Vernon; Chouraki, Vincent; Thomas, Charlene; Arfan Ikram, M.; Zélénika, Diana; Vardarajan, Badri Narayan; Kamatani, Yoichiro; Lin, Chiaofeng; Schmidt, Helena; Kunkle, Brian W.; Dunstan, Melanie L.; Vronskaya, Maria; Johnson, Andrew D.; Ruíz, Agustín R.; Bihoreau, Marie Thérèse; Reitz, Christiane; Pasquier, Florence; Hollingworth, Paul; Hanon, Olivier; Fitzpatrick, Annette L.; Buxbaum, Joseph D.; Campion, Dominique; Crane, Paul K.; Becker, Clinton Baldwin Tim; Gudnason, Vilmundur G.; Cruchaga, Carlos; Craig, David A.; Amin, Najaf; Berr, Claudine; López, Óscar L.; De Jager, Philip L.; Deramecourt, Vincent; Johnston, Janet A.; Evans, Denis Andrew; Lovestone, Simon; Letenneur, Luc U C; Hernández, Isabel Martínez; Rubinsztein, David C.; Eiríksdóttir, Gudný; Sleegers, Kristel; Goate, Alison M.; Fiévet, Nathalie; Huentelman, Matthew J J.; Gill, Michael; Brown, Kristelle S.; Kamboh, Mohammad Ilyas; Keller, Lina; Barberger-Gateau, Pascale; McGuinness, Bernadette M.; Larson, Eric B.; Myers, Amanda J.; Dufouil, Carole; Todd, Stephen A.; Wallon, David; Love, Seth; Rogaeva, Ekaterina A.; Gallacher, John E J; St. George-Hyslop, Peter; Clarimon, Jordi; Lleõ, Alberto; Bayer, A.; Tsuang, Debby W.; Yu, Lei; Tsolaki, Magda N.; Bossù, Paola; Spalletta, Gianfranco; Proitsi, Petra; Collinge, John C.; Sorbi, Sandro; Sánchez-García, Florentino; Fox, Nick C.; Hardy, John Anthony; Naranjo, Maria Candida Deniz; Bosco, Paolo; Clarke, Robert J.; Brayne, Carol E G; Galimberti, Daniela; Scarpini, Elio A.; Bonuccelli, Ubaldo; Mancuso, Michelangelo; Siciliano, Gabriele; Moebus, Susanne; Mecocci, Patrizia; Del Zompo, M.; Maier, Wolfgang A.; Hampel, Harald; Pilotto, Alberto; Frank García, Ana; Panza, Francesco; Solfrizzi, Vincenzo; Caffarra, Paolo; Nacmias, B.; Perry, William Lloyd; Mayhaus, Manuel; Lannfelt, Lars; Hákonarson, Hákon H.; Pichler, Sabrina; Carrasquillo, Minerva M.; Ingelsson, Martin; Beekly, Duane L.; Álvarez, Victoria Asensi; Zou, Fanggeng; Valladares, Otto; Younkin, Steven G.; Coto, Eliécer; Hamilton-Nelson, Kara L.; Gu, Wei; Razquin, Cristina; Pastor, Pau; Mateo, Ignacio; Owen, Michael John; Faber, Kelley M.; Jónsson, Pálmi Válmi; Combarros, Onofre; O'Donovan, M. C.; Cantwell, Laura B.; Soininen, Hilkka S.; Blacker, Deborah L.; Mead, Simon H.; Mosley, Thomas H.; Bennett, David Alan; Harris, Tamara B.; Fratiglioni, Laura; Holmes, Clive A.; De Bruijn, Renée Fag A G; Passmore, Peter A.; Montine, Thomas J.; Bettens, Karolien; Rotter, Jerome I.; Brice, Alexis; Morgan, Kevin N.; Foroud, Tatiana M.; Kukull, Walter A.; Hannequin, Didier; Powell, John F F; Nalls, Michael A.; Ritchie, Karen Anne; Lunetta, Kathryn L.; Kauwe, John S K; Boerwinkle, Eric Eric; Riemenschneider, Matthias; Boada, Merçé; Hiltunen, Mikko J.; Martin, Eden R.; Schmidt, Reinhold Ernst S; Rujescu, Dan A N; Dartigues -, Jean François; Mayeux, Richard P.; Tzourio, Christophe; Hofman, Albert; Nöthen, Markus M.; Graff, Caroline; Psaty, Bruce M.; Haines, Jonathan L.; Lathrop, Mark G.; Peričak-Vance, Margaret A O; Launer, Lenore J.; Van Broeckhoven, Christine L.; Farrer, Lindsay A A.; Van Duijn, Cornélia M.; Ramírez, Alfredo L.; Seshadri, Sudha; Schellenberg, Gerard David; Amouyel, Philippe; Williams, Julie I.
2014-06-12 -
Genetic landscape of 6089 inherited retinal dystrophies affected cases in Spain and their therapeutic and extended epidemiological implications
Perea-Romero, Irene; Gordo, Gema; Iancu, Ionut F.; Del Pozo-Valero, Marta; Almoguera, Berta; Blanco-Kelly, Fiona; Carreño, Ester; Jimenez-Rolando, Belen; Lopez-Rodriguez, Rosario; Lorda-Sanchez, Isabel; Martin-Merida, Inmaculada; Pérez de Ayala, Lucia; Riveiro-Alvarez, Rosa; Rodriguez-Pinilla, Elvira; Tahsin-Swafiri, Saoud; Trujillo-Tiebas, Maria J.; Bustamante-Aragones, Ana; Cardero-Merlo, Rocio; Fernandez-Sanchez, Ruth; Gallego-Merlo, Jesus; Garcia-Vara, Ines; Gimenez-Pardo, Ascension; Horcajada-Burgos, Laura; Infantes-Barbero, Fernando; Lantero, Esther; Lopez-Martinez, Miguel A.; Martinez-Ramas, Andrea; Ondo, Lorena; Rodriguez de Alba, Marta; Sanchez-Jimeno, Carolina; Velez-Monsalve, Camilo; Villaverde, Cristina; Zurita, Olga; Aguilera-Garcia, Domingo; Aguirre-Lamban, Jana; Arteche, Ana; Cantalapiedra, Diego; Fernandez-San Jose, Patricia; Galbis-Martinez, Liliana; Garcia-Hoyos, Maria; Lombardia, Carlos; Lopez-Molina, Maria I.; Perez-Carro, Raquel; Da Silva, Luciana R.J.; Ramos, Carmen; Sanchez-Alcudia, Rocio; Sanchez-Navarro, Iker; Tatu, Sorina D.; Vallespin, Elena; Aller, Elena; Bernal, Sara; Gamundi, Maria J.; Garcia-Garcia, Gema; Hernan, Inmaculada; Jaijo, Teresa; Antiñolo, Guillermo; Baiget, Montserrat; Carballo, Miguel; Millan, Jose M.; Valverde, Diana; Allikmets, Rando; Banfi, Sandro; Cremers, Frans P.M.; Collin, Rob W.J.; De Baere, Elfride; Hakonarson, Hakon; Kohl, Susanne; Rivolta, Carlo; Sharon, Dror; Alonso-Cerezo, Maria C.; Ballesta-Martinez, Maria J.; Beltran, Sergi; Benito Lopez, Carmen; Català-Mora, Jaume; Catalli, Claudio; Cotarelo-Perez, Carmen; Fernandez-Burriel, Miguel; Fontalba-Romero, Ana; Galán-Gómez, Enrique; Garcia-Barcina, Maria; Garcia-Cruz, Loida M.; Gener, Blanca; Gil-Fournier, Belen; Govea, Nancy; Guillen-Navarro, Encarna; Hernando Acero, Ines; Irigoyen, Cristina; Izquierdo-Álvarez, Silvia; Llano-Rivas, Isabel; López-Ariztegui, Maria A.; Lopez-Gonzalez, Vanesa; Lopez-Grondona, Fermina; Martorell, Loreto; Mendez-Perez, Pilar; Moreno-Igoa, Maria; Oancea-Ionescu, Raluca; Palau-Martinez, Francesc; Perez de Nanclares, Guiomar; Ramos-Fuentes, Feliciano J.; Rodriguez-Lopez, Raquel; Ayuso García, María del Carmen Tomasa
2021-12-01