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Prognosis Value of Immunoregulatory Molecules in Oral Cancer Microenvironment: An Immunohistochemical Study

Author
Peña-Cardelles, Juan Francisco; Pozo Kreilinger, José Juanuntranslated; Roncador, Giovanna; Esteban-Hernández, Jesús; Moro Rodríguez, José Ernesto; Sastre-Perona, Ana; Castelo Fernández, Beatrizuntranslated; Cebrián Carretero, José Luis
Entity
UAM. Departamento de Anatomía Patológica; UAM. Departamento de Anatomía, Histología y Neurociencia; UAM. Departamento de Medicina
Publisher
MDPI
Date
2022-03-19
Citation
10.3390/biomedicines10030710
Biomedicines 10.3 (2022): 710
 
 
 
ISSN
2227-9059
DOI
10.3390/biomedicines10030710
Funded by
This research was funded by the Fundación para la investigación Biomédica Hospital Universitario La Paz with the project number: EC_5474. The research has been partially funded through a predoctoral research grant awarded by the Official College of Dentists of Madrid (Madrid, Spain) with not project number associated
Editor's Version
https://doi.org/10.3390/biomedicines10030710
Subjects
microenvironment; oral cancer; PD-1; PD-L1; risk score; Medicina
URI
http://hdl.handle.net/10486/706687
Rights
© 2022 by the authors

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Objectives: To evaluate the relationship of the immune-checkpoint PD-1/PD-L1 with the clinical evolution of OSCC; to assess survival in OSCC based on the characteristics of TME and histologic risk score; to evaluate the clinical and histopathological relationship of OSCC with immunological TME. Material and Methods: A retrospective study was carried out on 65 samples from patients with OSCC on the floor of the mouth or tongue. Clinicopathological variables and the expression of the biomarkers PD-1, PD-L1, FoxP3, CD4, CD8, CSF1R, and p16 were recorded. The relationship of the clinical and histological variables with the expression of the biomarkers and survival was studied. Results: The univariate and multivariate analysis indicated that positive PD-1 expression was an independent protective factor for survival (overall, disease-free, disease-specific survival) and that high PD-L1 also improved survival. Poorly differentiated histological grades and metastasis were associated with a worse prognosis. Conclusions: PD-1 is a protective survival factor that is maintained independently of PD-L1 expression. High values of PD-L1 expression also improve survival. Higher expression of PD-1 is observed in smaller tumors, and higher expression of PD-L1 is more likely in women. No relationship between the tumor microenvironment and histologic risk score was found to influence the survival patterns studied in the OSCC. There is no evidence of a relationship between the histopathological features and the studied markers, although the positive PD-1 and PD-L1 cases have a lower risk of a high WPOI score, and positive PD-1 expression was associated with a lower DOI
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Google™ Scholar:Peña-Cardelles, Juan Francisco - Pozo Kreilinger, José Juan - Roncador, Giovanna - Esteban-Hernández, Jesús - Moro Rodríguez, José Ernesto - Sastre-Perona, Ana - Castelo Fernández, Beatriz - Cebrián Carretero, José Luis

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  • Producción científica en acceso abierto de la UAM [16850]

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