dc.contributor.author | Peña-Cardelles, Juan Francisco | |
dc.contributor.author | Pozo Kreilinger, José Juan | |
dc.contributor.author | Roncador, Giovanna | |
dc.contributor.author | Esteban-Hernández, Jesús | |
dc.contributor.author | Moro Rodríguez, José Ernesto | |
dc.contributor.author | Sastre-Perona, Ana | |
dc.contributor.author | Castelo Fernández, Beatriz | |
dc.contributor.author | Cebrián Carretero, José Luis | |
dc.contributor.other | UAM. Departamento de Anatomía Patológica | es_ES |
dc.contributor.other | UAM. Departamento de Anatomía, Histología y Neurociencia | es_ES |
dc.contributor.other | UAM. Departamento de Medicina | es_ES |
dc.date.accessioned | 2023-03-17T18:13:22Z | |
dc.date.available | 2023-03-17T18:13:22Z | |
dc.date.issued | 2022-03-19 | |
dc.identifier.citation | Biomedicines 10.3 (2022): 710 | en_US |
dc.identifier.issn | 2227-9059 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/706687 | |
dc.description.abstract | To evaluate the relationship of the immune-checkpoint PD-1/PD-L1 with the clinical evolution of OSCC; to assess survival in OSCC based on the characteristics of TME and histologic risk score; to evaluate the clinical and histopathological relationship of OSCC with immunological TME. Material and Methods: A retrospective study was carried out on 65 samples from patients with OSCC on the floor of the mouth or tongue. Clinicopathological variables and the expression of the biomarkers PD-1, PD-L1, FoxP3, CD4, CD8, CSF1R, and p16 were recorded. The relationship of the clinical and histological variables with the expression of the biomarkers and survival was studied. Results: The univariate and multivariate analysis indicated that positive PD-1 expression was an independent protective factor for survival (overall, disease-free, disease-specific survival) and that high PD-L1 also improved survival. Poorly differentiated histological grades and metastasis were associated with a worse prognosis. PD-1 is a protective survival factor that is maintained independently of PD-L1 expression. High values of PD-L1 expression also improve survival. Higher expression of PD-1 is observed in smaller tumors, and higher expression of PD-L1 is more likely in women. No relationship between the tumor microenvironment and histologic risk score was found to influence the survival patterns studied in the OSCC. There is no evidence of a relationship between the histopathological features and the studied markers, although the positive PD-1 and PD-L1 cases have a lower risk of a high WPOI score, and positive PD-1 expression was associated with a lower DOI | en_US |
dc.description.sponsorship | This research was funded by the Fundación para la investigación Biomédica Hospital Universitario La Paz with the project number: EC_5474. The research has been partially funded through a predoctoral research grant awarded by the Official College of Dentists of Madrid (Madrid, Spain) with not project number associated | en_US |
dc.format.extent | 20 pag. | es_ES |
dc.format.mimetype | application/pdf | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.relation.ispartof | Biomedicines | en_US |
dc.rights | © 2022 by the authors | en_US |
dc.subject.other | microenvironment | en_US |
dc.subject.other | oral cancer | en_US |
dc.subject.other | PD-1 | en_US |
dc.subject.other | PD-L1 | en_US |
dc.subject.other | risk score | en_US |
dc.title | Prognosis value of immunoregulatory molecules in oral cancer microenvironment: an immunohistochemical study | en_US |
dc.type | article | en_US |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/biomedicines10030710 | en_US |
dc.identifier.doi | 10.3390/biomedicines10030710 | en_US |
dc.identifier.publicationfirstpage | 710-1 | es_ES |
dc.identifier.publicationissue | 3 | es_ES |
dc.identifier.publicationlastpage | 710-20 | es_ES |
dc.identifier.publicationvolume | 10 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en_US |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en_US |
dc.facultadUAM | Facultad de Medicina | es_ES |