Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
Treatment with the senolytics dasatinib/quercetin reduces SARS-CoV-2-related mortality in mice
Author
Pastor-Fernández, Andrés; Bertos, Antonio R.; Sierra-Ramírez, Arantzazu; Moral Salmoral, Javier de; Merino, Javier; de Ávila, Ana I.; Olagüe, Cristina; Villares, Ricardo; González-Aseguinolaza, Gloria; Rodríguez, María Ángeles; Fresno Escudero, Manuel; Gironés Pujol, Nuria; Bustos, Matilde; Smerdou, Cristian; Fernandez-Marcos, Pablo Jose; von Kobbe, CayetanoEntity
UAM. Departamento de Biología MolecularPublisher
Wiley Open AccessDate
2023-01-26Citation
10.1111/acel.13771
Aging Cell 22.3 (2023): e13771
ISSN
1474-9718 (print); 1474-9726 (online)DOI
10.1111/acel.13771Project
Gobierno de España. SAF2017-85766-R; Gobierno de España. PID2020-114077RB-I00; Gobierno de España. PID2020-113888RB-I00Editor's Version
https://doi.org/10.1111/acel.13771Subjects
COVID-19; SARS-CoV-2; Cellular Senescence; Senolytics; Survival; Biología y Biomedicina / BiologíaRights
© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.Abstract
The enormous societal impact of the ongoing COVID-19 pandemic has been particularly harsh for some social groups, such as the elderly. Recently, it has been suggested that senescent cells could play a central role in pathogenesis by exacerbating the pro-inflammatory immune response against SARS-CoV-2. Therefore, the selective clearance of senescent cells by senolytic drugs may be useful as a therapy to ameliorate the symptoms of COVID-19 in some cases. Using the established COVID-19 murine model K18-hACE2, we demonstrated that a combination of the senolytics dasatinib and quercetin (D/Q) significantly reduced SARS-CoV-2-related mortality, delayed its onset, and reduced the number of other clinical symptoms. The increase in senescent markers that we detected in the lungs in response to SARS-CoV-2 may be related to the post-COVID-19 sequelae described to date. These results place senescent cells as central targets for the treatment of COVID-19, and make D/Q a new and promising therapeutic tool
Files in this item
Google Scholar:Pastor-Fernández, Andrés
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Bertos, Antonio R.
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Sierra-Ramírez, Arantzazu
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Moral Salmoral, Javier de
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Merino, Javier
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de Ávila, Ana I.
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Olagüe, Cristina
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Villares, Ricardo
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González-Aseguinolaza, Gloria
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Rodríguez, María Ángeles
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Fresno Escudero, Manuel
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Gironés Pujol, Nuria
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Bustos, Matilde
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Smerdou, Cristian
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Fernandez-Marcos, Pablo Jose
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von Kobbe, Cayetano
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