Enantioselective Suzuki cross-coupling of 1,2-diboryl cyclopropanes
Entity
UAM. Departamento de Química OrgánicaPublisher
Royal Society of ChemistryDate
2023-01-13Citation
10.1039/d2sc05789a
Chemical Science 14.6 (2023):
ISSN
2041-6520 (print); 2041-6539 (online)DOI
10.1039/d2sc05789aProject
Gobierno de España. PID2019-107380GB-I00Editor's Version
https://doi.org/10.1039/d2sc05789aSubjects
Hydroboration; Alkene; Diborane; QuímicaRights
© 2023 The Author(s). Published by the Royal Society of ChemistryAbstract
Herein, we describe the catalytic enantioselective cross-coupling of 1,2-bisboronic esters. Prior work on group specific cross coupling is limited to the use of geminal bis-boronates. This desymmetrization provides a novel approach to prepare enantioenriched cyclopropyl boronates with three contiguous stereocenters, that could be further derivatized through selective functionalization of the carbon-boron bond. Our results suggest that transmetallation, which is the enantiodetermining step, takes place with retention of stereochemistry at carbon
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Google Scholar:Teresa, Javier
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Velado, Marina
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Fernández de la Pradilla, Roberto
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Viso, Alma
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Lozano, Blanca
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Tortosa, Mariola
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