SOCS3 deregulation contributes to aberrant activation of the JAK/STAT pathway in precursor T-cell neoplasms
Author
Lahera Alonso, Antonio








Entity
UAM. Departamento de Biología; UAM. Departamento de Biología MolecularPublisher
WileyDate
2023-02-14Citation
10.1111/bjh.18694
British Journal of Haematology (2023): 14 February
ISSN
0007-1048 (print); 1365-2141 (online)DOI
10.1111/bjh.18694Funded by
Comunidad de Madrid, Grant/Award Number: B2017/BMD-3778; LINFOMAS-CM; Fundación Científica Asociación Española Contra el Cáncer, Grant/Award Number: PROYE18054PIRI; Fundación Ramón Areces, Grant/Award Number: CIVP19S7917; Instituto de Investigación Sanitaria Fundación Jiménez Díaz; Ministerio de Ciencia, Innovación y Universidades, Grant/ Award Number: RTI2018- 093330-B-I00 and MCIU/FEDER; Ministerio de Economía y Competitividad, Grant/Award Number: SAF2015-70561-R and MINECO/FEDERProject
Gobierno de España. RTI2018-093330-B-I00; Gobierno de España. SAF2015-70561-R; Comunidad de Madrid. B2017/BMD-3778/LINFOMAS-CMEditor's Version
https://doi.org/10.1111/bjh.18694Subjects
JAK/STAT pathway; Precursor T-cell neoplasms (T-ALL/LBL); SOCS3; Biología y Biomedicina / BiologíaRights
© 2023 The AuthorsAbstract
Despite the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway being frequently altered in T-ALL/LBL, no specific therapy has been approved for T-ALL/LBL patients with constitutive signalling by JAK/STAT, so there is an urgent need to identify pathway members that may be potential therapeutic targets. In the present study, we searched for JAK/STAT pathway members potentially modulated through aberrant methylation and identified SOCS3 hypermethylation as a recurrent event in T-ALL/LBL. Additionally, we explored the implications of SOCS3 deregulation in T-ALL/LBL and demonstrated that SOCS3 counteracts the constitutive activation of the JAK/STAT pathway through different molecular mechanisms. Therefore, SOCS3 emerges as a potential therapeutic target in T-ALL/LBL
Files in this item
Google Scholar:Lahera Alonso, Antonio
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López Nieva, María Pilar
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Alarcón Iniesta, Hernán
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Marín Rubio, José L.
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Cobos Fernández, María Ángeles
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Fernández Navarro, Pablo
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Fernández, Agustín F.
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Vela Martín, Laura
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Sastre, Isabel
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Ruiz García, Sara
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Llamas Sillero, Pilar
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López Lorenzo, José L.
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Cornago, Javier
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Santos, Javier
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Fernández Piqueras, José
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Villa Morales, María del Consuelo
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