MicroRNAs in autoimmune thyroid diseases and their role as biomarkers
EntityUAM. Departamento de Medicina
10.1016/j.beem.2023.101741Best Practice & Research Clinical Endocrinology & Metabolism 37.2 (2023): 101741
Funded byThis work was funding by Proyectos de Investigacion en Salud (PI) PI19-00584, PI22/01404 and PMP22-00021 (funded by Instituto de Salud Carlos III) and P2022/BMD7379 (funded by la Comunidad de Madrid) and cofinanced by FEDER funds to Mónica Marazuela and Rebeca Martínez-Hernández
SubjectsAutoimmune thyroid diseases; Biomarkers; Graves’ disease; Graves’ ophthalmopathy; Hashimoto thyroiditis; MicroRNAs; Medicina
Rights© 2023 The Authors
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the posttranscriptional level. They are emerging as potential biomarkers and as therapeutic targets for several diseases including autoimmune thyroid diseases (AITD). They control a wide range of biological phenomena, including immune activation, apoptosis, differentiation and development, proliferation and metabolism. This function makes miRNAs attractive as disease biomarker candidates or even as therapeutic agents. Because of their stability and reproducibility circulating miRNAs have been an interesting area of research in many diseases, and studies describing their role in the immune response and in autoimmune diseases have progressively developed. The mechanisms underlying AITD remain elusive. AITD pathogenesis is characterized by a multifactorial interplay based on the synergy between susceptibility genes and environmental stimulation, together with epigenetic modulation. Understanding the regulatory role of miRNAs could lead to identify potential susceptibility pathways, diagnostic biomarkers and therapeutic targets for this disease. Herein we update our present knowledge on the role of microRNAs in AITD and discuss on their importance as possible diagnostic and prognostic biomarkers in the most prevalent AITDs: Hashimoto's thyroiditis (HT), Graves' disease (GD) and Graves’ Ophthalmopathy (GO). This review provides an overview of the state of the art in the pathological roles of microRNAs as well as in possible novel miRNA-based therapeutic approaches in AITD
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Google Scholar:Martínez Hernández, Rebeca - Marazuela Azpiroz, Mónica
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