Effects of a mealworm (Tenebrio molitor) extract on metabolic syndrome-related pathologies: In vitro insulin sensitivity, inflammatory response, hypolipidemic activity and oxidative stress
EntityUAM. Departamento de Química Física Aplicada
10.3390/insects13100896Insects 13.10 (2022): 896
ProjectComunidad de Madrid. S2018/BAA-4343/ALIBIRD2020-CM; Gobierno de España. PID2021-122766OB-100; Gobierno de España. PID2021-122765OB-I00; info:eu-repo/grantAgreement/EC/H2020/721236/EU//TREATMENT
SubjectsEdible Insects; Hermetia Illucens; Insect; Ciencia y Tecnología de Alimentos
Rights© 2022 by the authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
The mealworm (Tenebrio molitor Linnaeus 1758) is gaining importance as one of the most popular edible insects. Studies focusing on its bioactivities are increasing, although alternative forms of consumption other than the whole insect or flour, such as bioactive non-protein extracts, remain underexplored. Furthermore, the incidence of metabolic syndrome-related pathologies keeps increasing, hence the importance of seeking novel natural sources for reducing the impact of certain risk factors. The aim was to study the potential of a non-protein mealworm extract on metabolic syndrome-related pathologies, obtained with ethanol:water (1:1, v/v) by ultrasound-assisted extraction. We characterized the extract by gas-chromatography mass-spectrometry and assessed its hypolipidemic potential, its ability to scavenger free radicals, to attenuate the inflammatory response in microglial cells, to affect mitochondrial respiration and to enhance insulin sensitivity in mouse hepatocytes. The extract contained fatty acids, monoglycerides, amino acids, certain acids and sugars. The mealworm extract caused a 30% pancreatic lipase inhibition, 80% DPPH· scavenging activity and 55.9% reduction in the bioaccessibility of cholesterol (p = 0.009). The extract was effective in decreasing iNOS levels, increasing basal, maximal and ATP coupled respiration as well as enhancing insulin-mediated AKT phosphorylation at low insulin concentrations (p < 0.05). The potential of a non-protein bioactive mealworm extract against metabolic syndrome-related pathologies is shown, although further studies are needed to elucidate the mechanisms and relationship with compounds
Google Scholar:Navarro del Hierro, Joaquín - Cantero Bahíllo, Emma - Fernández-Felipe, M. Teresa - Rodríguez García-Risco, Mónica - Fornari Reale, Tiziana - Rada, Patricia - Doblado, Laura - Ferreira, Vitor - Hitos, Ana B. - Valverde, Ángela M. - Monsalve, María - Martín García, Diana
This item appears in the following Collection(s)
Showing items related by title, author, creator and subject.
Increased hypothalamic anti‐inflammatory mediators in non‐diabetic insulin receptor substrate 2‐deficient mice
Simultaneous supercritical fluid extraction of heather (Calluna vulgaris L.) and marigold (Calendula officinalis L.) and anti-inflammatory activity of the extracts
Ultrasound-assisted extraction and bioaccessibility of saponins from edible seeds: quinoa, lentil, fenugreek, soybean and lupin