Effects of a mealworm (Tenebrio molitor) extract on metabolic syndrome-related pathologies: In vitro insulin sensitivity, inflammatory response, hypolipidemic activity and oxidative stress
Entity
UAM. Departamento de Química Física AplicadaPublisher
MDPIDate
2022-10-01Citation
10.3390/insects13100896
Insects 13.10 (2022): 896
ISSN
2075-4450 (online)DOI
10.3390/insects13100896Project
Comunidad de Madrid. S2018/BAA-4343/ALIBIRD2020-CM; Gobierno de España. PID2021-122766OB-100; Gobierno de España. PID2021-122765OB-I00; info:eu-repo/grantAgreement/EC/H2020/721236/EU//TREATMENTEditor's Version
https://doi.org/10.3390/insects13100896Subjects
Edible Insects; Hermetia Illucens; Insect; Ciencia y Tecnología de AlimentosRights
© 2022 by the authorsAbstract
The mealworm (Tenebrio molitor Linnaeus 1758) is gaining importance as one of the most popular edible insects. Studies focusing on its bioactivities are increasing, although alternative forms of consumption other than the whole insect or flour, such as bioactive non-protein extracts, remain underexplored. Furthermore, the incidence of metabolic syndrome-related pathologies keeps increasing, hence the importance of seeking novel natural sources for reducing the impact of certain risk factors. The aim was to study the potential of a non-protein mealworm extract on metabolic syndrome-related pathologies, obtained with ethanol:water (1:1, v/v) by ultrasound-assisted extraction. We characterized the extract by gas-chromatography mass-spectrometry and assessed its hypolipidemic potential, its ability to scavenger free radicals, to attenuate the inflammatory response in microglial cells, to affect mitochondrial respiration and to enhance insulin sensitivity in mouse hepatocytes. The extract contained fatty acids, monoglycerides, amino acids, certain acids and sugars. The mealworm extract caused a 30% pancreatic lipase inhibition, 80% DPPH· scavenging activity and 55.9% reduction in the bioaccessibility of cholesterol (p = 0.009). The extract was effective in decreasing iNOS levels, increasing basal, maximal and ATP coupled respiration as well as enhancing insulin-mediated AKT phosphorylation at low insulin concentrations (p < 0.05). The potential of a non-protein bioactive mealworm extract against metabolic syndrome-related pathologies is shown, although further studies are needed to elucidate the mechanisms and relationship with compounds
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Google Scholar:Navarro del Hierro, Joaquín
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Cantero Bahíllo, Emma
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Fernández-Felipe, M. Teresa
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Rodríguez García-Risco, Mónica
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Fornari Reale, Tiziana
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Rada, Patricia
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Doblado, Laura
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Ferreira, Vitor
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Hitos, Ana B.
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Valverde, Ángela M.
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Monsalve, María
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Martín García, Diana
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