Encapsulation of marjoram phenolic compounds using chitosan to improve its colon delivery
EntityUAM. Departamento de Química Física Aplicada
10.3390/foods11223657Foods 11.22 (2022): 3657
Funded byThis research was funded by the Spanish Government (Project: PID2019-110183RBC22/AEI/10.13039/501100011033) and by Comunidad Autónoma de Madrid (ALIBIRD2020-CM, S2018/BAA-4343)
ProjectGobierno de España. PID2019-110183RB-C22; Comunidad de Madrid. P2018/BAA-4343/ALIBIRD2020-CM
SubjectsChitosan-Tripolyphosphate; Chitosan; Drug Delivery Systems; Física; Química
Rights© 2022 The Author(s)
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
In this study, chitosan particles were used to encapsulate marjoram phenolic compounds as colon-specific drug-delivery systems. The microparticles were prepared by ionic gelation and spray-drying techniques and varying amounts of polymer and extract, along with different method conditions. The spray drying of microparticles (0.75% low molecular weight chitosan dissolved in 0.4% of acetic acid) presented the best encapsulation efficiency (near 75%), with size ranges from 1.55 to 1.68 µm that allowed the encapsulation of 1.25–1.88 mg/mL of extract. Release studies of individual marjoram phenolic compounds at pH 2 and 7.4 showed that most of the compounds remained encapsulated in the microparticles. Only arbutin and vicenin II presented a high initial burst release. As the polarity of the compounds was reduced, their initial release decreased. In addition, after gastrointestinal digestion, most of marjoram phenolic compounds remained encapsulated. These results prove that chitosan microparticlescould protect the marjoram phenolic compounds during gastrointestinal digestion, specifically those related to anticancer activity, which enables their application as colon-specific delivery systems
Google Scholar:Siles Sánchez, María de las Nieves - Jaime de Pablo, Laura - Villalva, Marisol - Santoyo Díez, Susana
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