Picornavirus translation strategies
Entity
UAM. Departamento de Biología MolecularPublisher
WileyDate
2022-06-01Citation
10.1002/2211-5463.13400
FEBS Open Bio 12.6 (2022): 1125 - 1141
ISSN
2211-5463 (online)DOI
10.1002/2211-5463.13400Funded by
This work was supported by grants PID2020-115096RB-I00 (MICIN), B2017/BMD-3770 (cofinanced by Autonomous Community of Madrid and FEDER funds), and an Institutional grant from Fundación Ramón ArecesProject
Gobierno de España. PID2020-115096RB-I00; Comunidad de Madrid. S2017/BMD-3770/RYPSE-CMEditor's Version
https://doi.org/10.1002/2211-5463.13400Subjects
Viral Protein; Messenger RNA; Protein Binding; Ribosomal Subunit; Virus Gene; Virus Genome; Biología y Biomedicina / BiologíaRights
© 2022 The Author(s)Abstract
The genome of viruses classified as picornaviruses consists of a single monocistronic positive strand RNA. The coding capacity of these RNA viruses is rather limited, and thus, they rely on the cellular machinery for their viral replication cycle. Upon the entry of the virus into susceptible cells, the viral RNA initially competes with cellular mRNAs for access to the protein synthesis machinery. Not surprisingly, picornaviruses have evolved specialized strategies that successfully allow the expression of viral gene products, which we outline in this review. The main feature of all picornavirus genomes is the presence of a heavily structured RNA element on the 5´UTR, referred to as an internal ribosome entry site (IRES) element, which directs viral protein synthesis as well and, consequently, triggers the subsequent steps required for viral replication. Here, we will summarize recent studies showing that picornavirus IRES elements consist of a modular structure, providing sites of interaction for ribosome subunits, eIFs, and a selective group of RNA-binding proteins
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Google Scholar:Francisco Velilla, María del Rosario
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Embarc Buh, Azman
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Abellan, Salvador
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Martínez Salas, Encarnación
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