Potent virucidal activity in vitro of photodynamic therapy with Hpericum extract as photosensitizer and white light against human coronavirus HCoV-229E
Entity
UAM. Departamento de Biología; UAM. Departamento de Biología MolecularPublisher
MDPIDate
2022-11-02Citation
10.3390/pharmaceutics14112364
Pharmaceutics 14.11 (2022): 2364
ISSN
1999-4923 (online)DOI
10.3390/pharmaceutics14112364Funded by
This research was funded by Fundación Universidad Autónoma de Madrid, grant number PI21/00315 and by Instituto de Salud Carlos III, grant number PI21/00953. Institutional Review Board Statement: Not applicableEditor's Version
https://doi.org/10.3390/pharmaceutics14112364Subjects
Animal Cell; Huh-7 Cell Line; Virucidal Activity; White Light; Biología y Biomedicina / BiologíaRights
© 2022 The Author(s)Abstract
The emergent human coronavirus SARS-CoV-2 and its high infectivity rate has highlighted the strong need for new virucidal treatments. In this sense, the use of photodynamic therapy (PDT) with white light, to take advantage of the sunlight, is a potent strategy for decreasing the virulence and pathogenicity of the virus. Here, we report the virucidal effect of PDT based on Hypericum extract (HE) in combination with white light, which exhibits an inhibitory activity of the human coronavirus HCoV-229E on hepatocarcinoma Huh-7 cells. Moreover, despite continuous exposure to white light, HE has long durability, being able to maintain the prevention of viral infection. Given its potent in vitro virucidal capacity, we propose HE in combination with white light as a promising candidate to fight against SARS-CoV-2 as a virucidal compound
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Google Scholar:Praena García, Beatriz
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Mascaraque Checa, Marta
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Andreu, Sabina
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Bello-Morales Arroyo, Ángeles Raquel
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Abarca-Lachen, Edgar
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Rapozzi, Valentina
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Gilaberte, Yolanda
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González, Salvador
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López Guerrero, José Antonio
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Juarranz de la Fuente, Ángeles
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