Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in multiple sclerosis
Entity
UAM. Departamento de MedicinaPublisher
ElsevierDate
2023-07-03Citation
10.1016/j.bbi.2023.06.025
Brain, Behavior and Immunity 113 (2023): 44-55
ISSN
1090-2139 (online); 0889-1591 (print)DOI
10.1016/j.bbi.2023.06.025Funded by
We greatly appreciate the support of Morote Traducciones S.L. for their editing assistance. This work was sponsored by a grant from Miguel Servet (CP20/00024 to Laura Otero-Ortega), Miguel Servet (CPII20/00002 to María Guti´errez-Fernández), a predoctoral fellowship (FI18/00026 to Fernando Laso-García), a Río-Hortega grant (CM22/00065 to Gabriel Torres Iglesias and CM20/00047 to Elisa Alonso-Lopez) and byResearch Project (PI21/00918) from the Instituto de Salud Carlos III and co-funded by the European Union and by a grant CA1/RSUE/2021-00753 to Dolores Piniella funded by Ministerio de Universidades, Plan de Recuperacion, ´ Transformacion ´ y Resiliencia y la Universidad Autónoma de MadridProject
Gobierno de España. PI21/00918Editor's Version
https://doi.org/10.1016/j.bbi.2023.06.025Subjects
biomarkers; blood; exosomes; extracellular vesicles; multiple sclerosis; proteomic analysis; rheumatoid arthritis; subcortical stroke; MedicinaRights
© 2023 The Author(s)Abstract
Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is
unpredictable. Finding biomarkers that help to better comprehend the disease’s pathogenesis is crucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles secreted by all cell types that contain information on the disease’s pathological processes.
Purpose: To identify the immune and nervous system-derived EV profile from blood that could have a specific role as biomarker in MS and assess its possible correlation with disease state.
Results: Higher levels of T cell-derived EVs and smaller size of neuron-derived EVs were associated with clinical relapse. The smaller size of the oligodendrocyte-derived EVs was related with motor and cognitive impairment.
The proteomic analysis identified mannose-binding lectin serine protease 1 and complement factor H from
immune system cell-derived EVs as autoimmune disease-associated proteins. We observed hepatocyte growth factor-like protein in EVs from T cells and inter-alpha-trypsin inhibitor heavy chain 2 from neurons as white matter injury-related proteins. In patients with MS, a specific protein profile was found in the EVs, higher levels of alpha-1-microglobulin and fibrinogen β chain, lower levels of C1S and gelsolin in the immune system-released vesicles, and Talin-1 overexpression in oligodendrocyte EVs. These specific MS-associated proteins, as well as myelin basic protein in oligodendrocyte EVs, correlated with disease activity in the patients with MS. Conclusion: Neural-derived and immune-derived EVs found in blood appear to be good specific biomarkers in MSfor reflecting the disease state
Files in this item
Google Scholar:Torres-Iglesias, Gabriel
-
Fernández-Fournier, Mireya
-
Botella, Lucía
-
Piniella Alcalde, Dolores
-
Laso-García, Fernando
-
Gómez-de Frutos, Mari Carmen
-
Chamorro, Beatriz
-
Puertas, Inmaculada
-
Tallón Barranco, Antonio
-
Fuentes Gimeno, Blanca Eulalia
-
Alonso de Leciñana Cases, María
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Protein content of blood-derived extracellular vesicles: an approach to the pathophysiology of cerebral hemorrhage
Laso-García, Fernando; Piniella Alcalde, Dolores; Gómez-De Frutos, Mari Carmen; Casado-Fernández, Laura; Pérez-Mato, María; Alonso López, Elisa; Otero Ortega, Laura; Belén Bravo, Susana; Chantada Vázquez, María del Pilar; Trilla Fuertes, Lucía; Fresno Vara, Juan Ángel; Fuentes Gimeno, Blanca Eulalia; Díez Tejedor, Exuperio; Gutiérrez Fernández, María; Alonso de Leciñana Cases, María
2023-01-19 -
Circulating extracellular vesicles promote recovery in a preclinical model of intracerebral hemorrhage
Laso-García, Fernando; Casado-Fernández, Laura; Piniella Alcalde, Dolores; Gómez-De Frutos, Mari Carmen; Arizaga Echebarria, Jone Karmele; Pérez-Mato, María; Alonso López, Elisa; Otero Ortega, Laura; Bravo, Susana B.; Chantada Vázquez, María del Pilar; Avendaño Ortiz, José; López Collazo, Eduardo; Lumbreras-Herrera, María Isabel; Gámez-Pozo, Angelo; Fuentes Gimeno, Blanca Eulalia; Díez Tejedor, Exuperio; Gutiérrez Fernández, María; Alonso de Leciñana Cases, María
2023