Chronic treatment with somatostatin analogues in recurrent type 1 gastric neuroendocrine tumors
Entity
UAM. Departamento de MedicinaPublisher
MDPIDate
2023-03-13Citation
10.3390/biomedicines11030872
Biomedicines 11.3 (2023): 872
ISSN
2227-9059 (online)DOI
10.3390/biomedicines11030872Editor's Version
https://doi.org/10.3390/biomedicines11030872Subjects
gastric neuroendocrine tumors; gastric carcinoids; somatostatin analogs; lanreotide; octreotide; MedicinaRights
© 2023 by the authorsAbstract
Type 1 gastric neuroendocrine tumors (GC-1) represent an uncommon subtype
of neoplasms. Endoscopic resection has been proposed as the treatment of choice; active surveillance may be performed in those smaller than 1 cm, while gastric surgery may be performed for those with frequent recurrences. The antiproliferative effect of somatostatin analogues (SSA) is well known, and their action on GC-1s has been postulated as a chronic treatment to reduce recurrence.
Methods: A two-centered, retrospective, observational study that included nine patients (55.6% women) diagnosed with GC-1, receiving long-term treatment with SSA, with a median follow-up from baseline of 22 months, was undertaken. Endoscopic follow-up, extension study, and analytical values of chromogranin A (Cg A) and gastrin were collected. Results: In total, 88.9% of patients presented partial or complete response. Treatment with SSA was the only independent factor with a trend to prevent tumor recurrence (Odds Ratio 0.054; p = 0.005). A nonsignificant tendency toward a decrease in CgA and gastrin was observed; lack of significance was probably related to concomitant
treatment with proton pump inhibitors in some patients. Conclusions: Chronic treatment with SSA is a feasible option for recurrent GC-1s that are difficult to manage using endoscopy or gastrectomy. Randomized clinical trials to provide more scientific evidence are still needed
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Google Scholar:Sebastian-Valles, Fernando
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Bernaldo Madrid, Blanca
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Sager, Carolina
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Carrillo López, Elena
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Mera Carreiro, Sara
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Ávila Antón, Laura
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Sánchez-Maroto García, Noelia
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Sampedro Núñez, Miguel Antonio
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Díaz Pérez, Jose Ángel
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Marazuela Azpiroz, Mónica
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