The role of herpes simplex virus type 1 infection in demyelination of the central nervous system
EntityUAM. Departamento de Biología Molecular
PublisherMultidisciplinary Digital Publishing Institute
10.3390/ijms21145026International Journal of Molecular Sciences 21.14 (2020): 5026
Funded byFinancial support for the study was provided by Fundación Severo Ochoa-Aeromédica Canaria. The funders had no role in the decision to publish or preparation of the manuscript
SubjectsCentral nervous system; Demyelination; Endogenous retroviruses; HSV-1; Molecular mimicry; Oligodendrocytes; Peripheral nervous system; Biología y Biomedicina / Biología
Rights© 2020, the author(s)
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Herpes simplex type 1 (HSV-1) is a neurotropic virus that infects the peripheral and central nervous systems. After primary infection in epithelial cells, HSV-1 spreads retrogradely to the peripheral nervous system (PNS), where it establishes a latent infection in the trigeminal ganglia (TG). The virus can reactivate from the latent state, traveling anterogradely along the axon and replicating in the local surrounding tissue. Occasionally, HSV-1 may spread trans-synaptically from the TG to the brainstem, from where it may disseminate to higher areas of the central nervous system (CNS). It is not completely understood how HSV-1 reaches the CNS, although the most accepted idea is retrograde transport through the trigeminal or olfactory tracts. Once in the CNS, HSV-1 may induce demyelination, either as a direct trigger or as a risk factor, modulating processes such as remyelination, regulation of endogenous retroviruses, or molecular mimicry. In this review, we describe the current knowledge about the involvement of HSV-1 in demyelination, describing the pathways used by this herpesvirus to spread throughout the CNS and discussing the data that suggest its implication in demyelinating processes
Google Scholar:Andreu, Sabina - Bello-Morales Arroyo, Ángeles Raquel - López Guerrero, José Antonio
This item appears in the following Collection(s)
Showing items related by title, author, creator and subject.