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dc.contributor.authorAndreu, Sabinaes_ES
dc.contributor.authorBello-Morales Arroyo, Ángeles Raquel es_ES
dc.contributor.authorLópez Guerrero, José Antonio es_ES
dc.contributor.otherUAM. Departamento de Biología Moleculares_ES
dc.date.accessioned2023-11-06T16:00:01Zen_US
dc.date.available2023-11-06T16:00:01Zen_US
dc.date.issued2020-07-16en_US
dc.identifier.citationInternational Journal of Molecular Sciences 21.14 (2020): 5026en_US
dc.identifier.issn1661-6596es_ES
dc.identifier.urihttp://hdl.handle.net/10486/708875en_US
dc.description.abstractHerpes simplex type 1 (HSV-1) is a neurotropic virus that infects the peripheral and central nervous systems. After primary infection in epithelial cells, HSV-1 spreads retrogradely to the peripheral nervous system (PNS), where it establishes a latent infection in the trigeminal ganglia (TG). The virus can reactivate from the latent state, traveling anterogradely along the axon and replicating in the local surrounding tissue. Occasionally, HSV-1 may spread trans-synaptically from the TG to the brainstem, from where it may disseminate to higher areas of the central nervous system (CNS). It is not completely understood how HSV-1 reaches the CNS, although the most accepted idea is retrograde transport through the trigeminal or olfactory tracts. Once in the CNS, HSV-1 may induce demyelination, either as a direct trigger or as a risk factor, modulating processes such as remyelination, regulation of endogenous retroviruses, or molecular mimicry. In this review, we describe the current knowledge about the involvement of HSV-1 in demyelination, describing the pathways used by this herpesvirus to spread throughout the CNS and discussing the data that suggest its implication in demyelinating processesen_US
dc.description.sponsorshipFinancial support for the study was provided by Fundación Severo Ochoa-Aeromédica Canaria. The funders had no role in the decision to publish or preparation of the manuscripten_US
dc.format.extent19 pag.en_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen_US
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.rights© 2020, the author(s)en_US
dc.subject.otherCentral nervous systemen_US
dc.subject.otherDemyelinationen_US
dc.subject.otherEndogenous retrovirusesen_US
dc.subject.otherHSV-1en_US
dc.subject.otherMolecular mimicryen_US
dc.subject.otherOligodendrocytesen_US
dc.subject.otherPeripheral nervous systemen_US
dc.titleThe role of herpes simplex virus type 1 infection in demyelination of the central nervous systemen_US
dc.typearticleen_US
dc.subject.ecienciaBiología y Biomedicina / Biologíaes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms21145026en_US
dc.identifier.doi10.3390/ijms21145026es_ES
dc.identifier.publicationfirstpage5026-1es_ES
dc.identifier.publicationissue14es_ES
dc.identifier.publicationlastpage5026-19es_ES
dc.identifier.publicationvolume21es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen_US
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen_US
dc.facultadUAMFacultad de Cienciases_ES


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