Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections
Entity
UAM. Departamento de Biología MolecularDate
2020-06-30Citation
10.3390/ijms21134675
International Journal of Molecular Sciences 21.13 (2020): 4675
ISSN
1661-6596DOI
10.3390/ijms21134675Funded by
Work in DPS laboratory is supported by Grants from Agencia Estatal de Investigación, MINECO/FEDER, Spain, RTI2018-097624-B-I00, Instituto de Salud Carlos III/FEDER, RETIC Aradyal RD16/0006/0021, and CSIC PTI Global Health (PIE 202020E223/CSIC-COVID-19-100). IR research is partially supported by the NIH/National Institute of Allergy and Infectious Diseases-funded centers PRIME (Program for Research on Immune Modeling and Experimentation, U19AI117873), and DHIPC (Dengue Human Immunology Project Consortium, 1U19AI118610).Project
Gobierno de España. RTI2018-097624-B-I00Subjects
Vimentin; Cell surface vimentin; SARS-CoV; Vimentin–pathogen interactions; Anti-vimentin autoantibodies; Inflammation; Intermediate filaments; Posttranslational modifications; Tissue damage and repair; Immune response; Biología y Biomedicina / BiologíaRights
© 2020, the author(s)Abstract
Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration. Consequently,
vimentin has complex implications in pathophysiology. Vimentin is required for a proper immune
response, but it can also act as an autoantigen in autoimmune diseases or as a damage signal.
Although vimentin is a predominantly cytoplasmic protein, it can also appear at extracellular
locations, either in a secreted form or at the surface of numerous cell types, often in relation to
cell activation, inflammation, injury or senescence. Cell surface targeting of vimentin appears to
associate with the occurrence of certain posttranslational modifications, such as phosphorylation
and/or oxidative damage. At the cell surface, vimentin can act as a receptor for bacterial and viral
pathogens. Indeed, vimentin has been shown to play important roles in virus attachment and entry
of severe acute respiratory syndrome-related coronavirus (SARS-CoV), dengue and encephalitis
viruses, among others. Moreover, the presence of vimentin in specific virus-targeted cells and its
induction by proinflammatory cytokines and tissue damage contribute to its implication in viral
infection. Here, we recapitulate some of the pathophysiological implications of vimentin, including
the involvement of cell surface vimentin in interaction with pathogens, with a special focus on its role
as a cellular receptor or co-receptor for viruses. In addition, we provide a perspective on approaches
to target vimentin, including antibodies or chemical agents that could modulate these interactions
to potentially interfere with viral pathogenesis, which could be useful when multi-target antiviral
strategies are needed
Files in this item
Google Scholar:Ramos, Irene
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Stamatakis Andriani, Konstantinos
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L. Oeste, clara
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Pérez- Sala, Dolores
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