Physical activity and association between frailty and all-causeand cardiovascular mortality in older adults: population-based prospective cohort study
Entity
UAM. Departamento de Educación Física, Deporte y Motricidad Humana; UAM. Departamento de MedicinaPublisher
WileyDate
2018-05Citation
10.1111/jgs.15542
Journal of the American Geriatrics Society 66.11 (2018): 2097-2103
ISSN
1532-5415 (online); 0002-8614 (print)DOI
10.1111/jgs.15542Editor's Version
https://doi.org/10.1111/jgs.15542Subjects
frailty; physical activity; elderly; mortality; MedicinaRights
© 2018 Copyright the Authors Journal compilation 2018, The American Geriatrics SocietyAbstract
Objectives: To examine the separate and joint association between physical activity and frailty and long-term all-cause and cardiovascular disease (CVD) mortality in older adults. Design: Population-based prospective cohort study. Setting: Cohort representative of the noninstitutionalized Spanish population.
Participants: Individuals aged 60 and older (N=3,896) in 2000-01. Measurements: Participants reported their physical activity using a validated instrument, and frailty was ascertained using the Fatigue, low Resistance, limitation in Ambulation, Illness and weight Loss (FRAIL) scale. Those with 0 frailty criteria were considered to be robust, with 1 or 2 criteria to be prefrail, and with 3 of more criteria to be frail. Participants were followed until 2014 to identify all-cause and CVD deaths. Associations were summarized using hazard ratios (HRs) and Cox regression after adjustment for main covariates.
Results: During a median 14 years of follow-up, 1,801 total deaths occurred, 672 from CVD. Compared with being robust, the multivariate hazard ratio (95% confidence interval) for all-cause mortality was 1.29 (1.14-1.45) in prefrail individuals, and 2.16 (1.82-2.58) in frail individuals (p-trend <.001). Compared with being physically inactive, being physically active was associated with a statistically significant 18% (1-32%), 28% (16-39%) and 39% (17-55%) lower all-cause mortality among robust, prefrail, and frail individuals, respectively (all p <.001). Compared with participants who were robust and physically active, those who were frail and inactive showed the highest all-cause mortality 2.45 (95%CI: 1.95-3.06); however, the hazard ratio (95% confidence interval) for all-cause mortality in frail individuals who were physically active was comparable to that in pre-frail and inactive participants: 1.70 (1.32-2.19) and 1.56 (1.34-1.82), respectively. Mortality of prefrail active participants was similar to that of robust inactive participants. Results were similar for CVD mortality
Files in this item
Google Scholar:Higueras Fresnillo, Sara
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Cabanas Sánchez, Verónica
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López García, Esther
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Esteban-Cornejo, Irene
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Banegas Banegas, José Ramón
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Sadarangani, Kabir P.
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Rodríguez Artalejo, Fernando
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Martínez Gómez, David
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