A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons

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dc.contributor.author Gabilondo, Hugo
dc.contributor.author Losada-Pérez, María
dc.contributor.author Saz, Delia del
dc.contributor.author Molina, Isabel
dc.contributor.author León, Yolanda
dc.contributor.author Canal, Inmaculada
dc.contributor.author Torroja, Laura
dc.contributor.author Benito-Sipos, Jonathan
dc.contributor.other UAM. Departamento de Biología es_ES
dc.date.accessioned 2014-06-03T13:55:10Z
dc.date.available 2014-06-03T13:55:10Z
dc.date.issued 2011
dc.identifier.citation Mechanisms of Development 128.3-4 (2011): 208-221 es_ES
dc.identifier.issn 0925-4773 es_ES
dc.identifier.uri http://hdl.handle.net/10486/660503
dc.description.abstract The central nervous system contains a wide variety of neuronal subclasses generated by neural progenitors. The achievement of a unique neural fate is the consequence of a sequence of early and increasingly restricted regulatory events, which culminates in the expression of a specific genetic combinatorial code that confers individual characteristics to the differentiated cell. How the earlier regulatory events influence post-mitotic cell fate decisions is beginning to be understood in the Drosophila NB 5-6 lineage. However, it remains unknown to what extent these events operate in other lineages. To better understand this issue, we have used a very highly specific marker that identifies a small subset of abdominal cells expressing the Drosophila neuropeptide Capa: the ABCA neurons. Our data support the birth of the ABCA neurons from NB 5-3 in a cas temporal window in the abdominal segments A2–A4. Moreover, we show that the ABCA neuron has an ABCA-sibling cell which dies by apoptosis. Surprisingly, both cells are also generated in the abdominal segments A5–A7, although they undergo apoptosis before expressing Capa. In addition, we have performed a targeted genetic screen to identify players involved in ABCA specification. We have found that the ABCA fate requires zfh2, grain, Grunge and hedgehog genes. Finally, we show that the NB 5-3 generates other subtype of Capa-expressing cells (SECAs) in the third suboesophageal segment, which are born during a pdm/cas temporal window, and have different genetic requirements for their specification. en_US
dc.description.sponsorship This work was supported by a grant from the Spanish Ministerio de Ciencia e Innovación (BFU-2008-04683-C02-02 to L.T.). es_ES
dc.format.extent 35 pag. es_ES
dc.format.mimetype application/pdf es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier Scientific es_ES
dc.relation.ispartof Mechanisms of Development es_ES
dc.subject.other Drosophila en_US
dc.subject.other Temporal genes en_US
dc.subject.other Neuropeptidergic cell identity en_US
dc.subject.other CAPA en_US
dc.subject.other Progenitor neuroblasts en_US
dc.title A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons en_US
dc.type article en
dc.subject.eciencia Biología y Biomedicina / Biología es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.mod.2011.01.002 es_ES
dc.identifier.doi 10.1016/j.mod.2011.01.002 es_ES
dc.identifier.publicationfirstpage 208 es_ES
dc.identifier.publicationissue 3-4 es_ES
dc.identifier.publicationlastpage 221 es_ES
dc.identifier.publicationvolume 128 es_ES
dc.relation.projectID Gobierno de España. BFU-2008-04683-C02-02 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.rights.accessRights openAccess en
dc.authorUAM León Álvarez, Yolanda (259040)
dc.authorUAM Losada Pérez, María (261918)
dc.authorUAM Torroja Fungairiño, Laura (260046)

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