A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons

Biblos-e Archivo/Manakin Repository

Show simple item record

dc.contributor.author Gabilondo, Hugo
dc.contributor.author Losada-Pérez, María
dc.contributor.author Saz, Delia del
dc.contributor.author Molina, Isabel
dc.contributor.author León, Yolanda
dc.contributor.author Canal, Inmaculada
dc.contributor.author Torroja, Laura
dc.contributor.author Benito-Sipos, Jonathan
dc.contributor.other UAM. Departamento de Biología es_ES
dc.date.accessioned 2014-06-03T13:55:10Z
dc.date.available 2014-06-03T13:55:10Z
dc.date.issued 2011
dc.identifier.citation Mechanisms of Development 128.3-4 (2011): 208-221 es_ES
dc.identifier.issn 0925-4773 es_ES
dc.identifier.uri http://hdl.handle.net/10486/660503
dc.description.abstract The central nervous system contains a wide variety of neuronal subclasses generated by neural progenitors. The achievement of a unique neural fate is the consequence of a sequence of early and increasingly restricted regulatory events, which culminates in the expression of a specific genetic combinatorial code that confers individual characteristics to the differentiated cell. How the earlier regulatory events influence post-mitotic cell fate decisions is beginning to be understood in the Drosophila NB 5-6 lineage. However, it remains unknown to what extent these events operate in other lineages. To better understand this issue, we have used a very highly specific marker that identifies a small subset of abdominal cells expressing the Drosophila neuropeptide Capa: the ABCA neurons. Our data support the birth of the ABCA neurons from NB 5-3 in a cas temporal window in the abdominal segments A2–A4. Moreover, we show that the ABCA neuron has an ABCA-sibling cell which dies by apoptosis. Surprisingly, both cells are also generated in the abdominal segments A5–A7, although they undergo apoptosis before expressing Capa. In addition, we have performed a targeted genetic screen to identify players involved in ABCA specification. We have found that the ABCA fate requires zfh2, grain, Grunge and hedgehog genes. Finally, we show that the NB 5-3 generates other subtype of Capa-expressing cells (SECAs) in the third suboesophageal segment, which are born during a pdm/cas temporal window, and have different genetic requirements for their specification. en_US
dc.description.sponsorship This work was supported by a grant from the Spanish Ministerio de Ciencia e Innovación (BFU-2008-04683-C02-02 to L.T.). es_ES
dc.format.extent 35 pag. es_ES
dc.format.mimetype application/pdf es_ES
dc.language.iso eng es_ES
dc.publisher Elsevier Scientific es_ES
dc.relation.ispartof Mechanisms of Development es_ES
dc.subject.other Drosophila en_US
dc.subject.other Temporal genes en_US
dc.subject.other Neuropeptidergic cell identity en_US
dc.subject.other CAPA en_US
dc.subject.other Progenitor neuroblasts en_US
dc.title A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons en_US
dc.type article en
dc.subject.eciencia Biología y Biomedicina / Biología es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.mod.2011.01.002 es_ES
dc.identifier.doi 10.1016/j.mod.2011.01.002 es_ES
dc.identifier.publicationfirstpage 208 es_ES
dc.identifier.publicationissue 3-4 es_ES
dc.identifier.publicationlastpage 221 es_ES
dc.identifier.publicationvolume 128 es_ES
dc.relation.projectID Gobierno de España. BFU-2008-04683-C02-02 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.rights.accessRights openAccess en
dc.authorUAM León Álvarez, Yolanda (259040)
dc.authorUAM Losada Pérez, María (261918)
dc.authorUAM Torroja Fungairiño, Laura (260046)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record