Biochemical markers of bone turnover and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: The TUGAMO study

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dc.contributor.author Alcaraz, A.
dc.contributor.author González-López, Raquel
dc.contributor.author Morote, J.
dc.contributor.author De La Piedra, Concepción
dc.contributor.author Meseguer, Cristina
dc.contributor.author Esteban, Emilio
dc.contributor.author Climent, Miguel Ángel
dc.contributor.author González-Gragera, B.
dc.contributor.author Álvarez-Ossorio, Jose Luis
dc.contributor.author Chirivella, Isabel
dc.contributor.author Mellado, Begoña
dc.contributor.author Lara, Pedro Carlos
dc.contributor.author Vázquez, Fernando Javier
dc.contributor.author Contreras Viedma, José Antonio
dc.contributor.author Carles, Joan
dc.contributor.author Murias, Adolfo
dc.contributor.author Calderero, Verónica
dc.contributor.author Comet-Batlle, Josep
dc.contributor.author González Del Alba, Aránzazu
dc.contributor.author León Mateos, Luis A.
dc.contributor.author Mañas, Ana
dc.contributor.author Segarra, José
dc.contributor.author Lassa, A.
dc.contributor.author González Enguita, Carmen
dc.contributor.author Méndez, Míriam J.
dc.contributor.author Samper, Pilar María
dc.contributor.author Unda, Miguel
dc.contributor.author Mahillo, Ignacio
dc.contributor.author Bellmunt, Joaquim
dc.contributor.author Alcaraz, A.
dc.contributor.author González-López, Raquel
dc.contributor.author Morote, J.
dc.contributor.author De La Piedra, Concepción
dc.contributor.author Meseguer, Cristina
dc.contributor.author Esteban, Emilio
dc.contributor.author Climent, Miguel Ángel
dc.contributor.author González-Gragera, B.
dc.contributor.author Álvarez-Ossorio, Jose Luis
dc.contributor.author Chirivella, Isabel
dc.contributor.author Mellado, Begoña
dc.contributor.author Lara, Pedro Carlos
dc.contributor.author Vázquez, Fernando Javier
dc.contributor.author Contreras, José Antonio Viedma
dc.contributor.author Carles, Joan
dc.contributor.author Murias, Adolfo
dc.contributor.author Calderero, Verónica
dc.contributor.author Comet-Batlle, Josep
dc.contributor.author González Del Alba, Aránzazu
dc.contributor.author León Mateos, Luis A.
dc.contributor.author Mañas, Ana
dc.contributor.author Segarra, José
dc.contributor.author Lassa, A.
dc.contributor.author González Enguita, Carmen
dc.contributor.author Méndez, Míriam J.
dc.contributor.author Samper, Pilar María
dc.contributor.author Unda, Miguel
dc.contributor.author Mahillo, Ignacio
dc.contributor.author Bellmunt, Joaquim
dc.contributor.other UAM. Departamento de Cirugía es_ES
dc.date.accessioned 2014-11-05T12:35:55Z
dc.date.available 2014-11-05T12:35:55Z
dc.date.issued 2013-07-09
dc.identifier.citation British Journal of Cancer 109 (2013): 121–130 en_US
dc.identifier.issn 0007-0920 (print) en_US
dc.identifier.issn 1532-1827 (online) en_US
dc.identifier.uri http://hdl.handle.net/10486/662416
dc.description.abstract Background: Levels of bone turnover markers (BTM) might be correlated with outcome in terms of skeletal-related events (SRE), disease progression, and death in patients with bladder cancer (BC) and renal cell carcinoma (RCC) with bone metastases (BM). We try to evaluate this possible correlation in patients who receive treatment with zoledronic acid (ZOL). Methods: This observational, prospective, and multicenter study analysed BTM and clinical outcome in these patients. Serum levels of bone alkaline phosphatase (BALP), procollagen type I amino-terminal propeptide (PINP), and beta-isomer of carboxyterminal telopeptide of type I collagen (b-CTX) were analysed. Results: Patients with RCC who died or progressed had higher baseline b-CTX levels and those who experienced SRE during follow-up showed high baseline BALP levels. In BC, a poor rate of survival was related with high baseline b-CTX and BALP levels, and new SRE with increased PINP levels. Cox univariate analysis showed that b-CTX levels were associated with higher mortality and disease progression in RCC and higher mortality in BC. Bone alkaline phosphatase was associated with increased risk of premature SRE appearance in RCC and death in BC. Conclusion: Beta-isomer of carboxy-terminal telopeptide of type I collagen and BALP can be considered a complementary tool for prediction of clinical outcomes in patients with BC and RCC with BM treated with ZOL en_US
dc.description.sponsorship Novartis Oncology Spain for supporting this study en_US
dc.format.extent 10 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Cancer Research UK en_US
dc.relation.ispartof British Journal of Cancer en_US
dc.rights © 2013 Cancer Research UK. All rights reserved 0007 – 0920/13 en_US
dc.subject.other Bladder cancer en_US
dc.subject.other Renal cell carcinoma en_US
dc.subject.other Bone markers en_US
dc.subject.other Overall survival en_US
dc.subject.other Disease progression en_US
dc.subject.other Skeletal-related events en_US
dc.title Biochemical markers of bone turnover and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: The TUGAMO study en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.1038/bjc.2013.272 es_ES
dc.identifier.doi 10.1038/bjc.2013.272 es_ES
dc.identifier.publicationfirstpage 121 es_ES
dc.identifier.publicationlastpage 130 es_ES
dc.identifier.publicationvolume 109 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en
dc.authorUAM González Enguita, María Del Carmen (261243)
dc.authorUAM González Enguita, María Del Carmen (261243)


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