Cell stress proteins in atherothrombosis

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dc.contributor.author Madrigal-Matute, Julio
dc.contributor.author Martínez-Pinna, Roxana
dc.contributor.author Fernandez-Garcia, Carlos Ernesto
dc.contributor.author Ramos-Mozo, Priscila
dc.contributor.author Burillo, Elena
dc.contributor.author Egido de los Ríos, Jesús
dc.contributor.author Blanco-Colio, Luís Miguel
dc.contributor.author Martín-Ventura, José Luis
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.date.accessioned 2015-02-23T09:12:57Z
dc.date.available 2015-02-23T09:12:57Z
dc.date.issued 2012-08-17
dc.identifier.citation Oxidative Medicine and Cellular Longevity 2012 (2012): 232464 es_ES
dc.identifier.issn 1942-0900 (print) en_US
dc.identifier.issn 1942-0994 (online) en_US
dc.identifier.uri http://hdl.handle.net/10486/663978
dc.description.abstract Cell stress proteins (CSPs) are a large and heterogenous family of proteins, sharing two main characteristics: their levels and/or location are modified under stress and most of them can exert a chaperon function inside the cells. Nonetheless, they are also involved in the modulation of several mechanisms, both at the intracellular and the extracellular compartments. There are more than 100 proteins belonging to the CSPs family, among them the thioredoxin (TRX) system, which is the focus of the present paper. TRX system is composed of several proteins such as TRX and peroxiredoxin (PRDX), two thiol-containing enzymes that are key players in redox homeostasis due to their ability to scavenge potential harmful reactive oxygen species. In addition to their main role as antioxidants, recent data highlights their function in several processes such as cell signalling, immune inflammatory responses, or apoptosis, all of them key mechanisms involved in atherothrombosis. Moreover, since TRX and PRDX are present in the pathological vascular wall and can be secreted under prooxidative conditions to the circulation, several studies have addressed their role as diagnostic, prognostic, and therapeutic biomarkers of cardiovascular diseases (CVDs) en_US
dc.description.sponsorship This work was supported by the Spanish Ministerio de Ciencia y Tecnología (SAF 2010-21852), Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Redes RECAVA (RD06/0014/0035),Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (PI10/00072), and Sociedad Española de Arterosclerosis and Fundación Lilly es_ES
dc.format.extent 10 pag. en
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.ispartof Oxidative Medicine and Cellular Longevity en_US
dc.rights © 2012 Julio Madrigal-Matute et al. es_ES
dc.subject.other antioxidant activity en_US
dc.subject.other apoptosis en_US
dc.subject.other blood vessel wall en_US
dc.subject.other cellular immunity en_US
dc.subject.other protein expression en_US
dc.subject.other thrombosis en_US
dc.title Cell stress proteins in atherothrombosis en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.identifier.doi 10.1155/2012/232464 es_ES
dc.identifier.publicationfirstpage 232464 es_ES
dc.identifier.publicationlastpage 232464 es_ES
dc.identifier.publicationvolume 2012 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Egido De Los Ríos, Jesús (259718)
dc.authorUAM Martínez-Pinna Albar, Roxana (264184)

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