Anterobasal temporal lobe lesions alter recurrent functional connectivity within the ventral pathway during naming

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Show simple item record Campo, Pablo es_ES Poch, Claudia es_ES Toledano, Rafael es_ES Igoa González, José Manuel es_ES Belinchón Carmona, Mercedes es_ES García Morales, Irene es_ES Gil Nagel, Antonio es_ES
dc.contributor.other UAM. Departamento de Psicología Básica es_ES 2015-05-28T14:44:29Z 2015-05-28T14:44:29Z 2013-07-31
dc.identifier.citation The Journal of Neuroscience 33.31 (2013): 12679-12688 en_US
dc.identifier.issn 0270-6474 (print) en_US
dc.identifier.issn 1529-2401 (online) en_US
dc.identifier.uri en_US
dc.description.abstract An increasing amount of evidence supports a crucial role for the anterior temporal lobe (ATL) in semantic processing. Critically, a selective disruption of the functional connectivity between left and right ATLs in patients with chronic aphasic stroke has been illustrated. The aim of the current study was to evaluate the consequences that lesions on the ATL have on the neurocognitive network supporting semantic cognition. Unlike previous work, in this magnetoencephalography study we selected a group of patients with small lesions centered on the left anteroventral temporal lobe before surgery. We then used an effective connectivity method (i.e., dynamic causal modeling) to investigate the consequences that these lesions have on the functional interactions within the network. This approach allowed us to evaluate the directionality of the causal interactions among brain regions and their associated connectivity strengths. Behaviorally, we found that semantic processing was altered when patients were compared with a strictly matched group of controls. Dynamic causal modeling for event related responses revealed that picture naming was associated with a bilateral frontotemporal network, encompassing feedforward and feedback connections. Comparison of specific network parameters between groups revealed that patients displayed selective network adjustments. Specifically, backward connectivity from anterior to posterior temporal lobe was decreased in the ipsilesional hemisphere, whereas it was enhanced in the contralesional hemisphere. These results reinforce the relevance of ATL in semantic memory, as well as its amodal organization, and highlight the role of feedback connections in enabling the integration of the semantic information. en_US
dc.description.sponsorship This work was supported by a research grant from the Spanish Ministry of Science and Innovation (Grant SAF2011-27920) to I.G.-M. P.C. was supported by a Ramo´n y Cajal Fellowship from the Spanish Ministry of Science and Innovation (RYC-2010-05748). C.P. was supported by Spanish Ministry of Science and Education (AP2009-4131). en_US
dc.format.extent 10 pag. es_ES
dc.format.mimetype application/pdf en_US
dc.language.iso eng en_US
dc.publisher Society of Neuroscience en_US
dc.relation.ispartof The Journal of Neuroscience en_US
dc.rights © 2013 the authors en_US
dc.subject.other Epilepsy en_US
dc.subject.other Lesions en_US
dc.subject.other Naming en_US
dc.subject.other Semantics en_US
dc.subject.other Temporal Lobe en_US
dc.title Anterobasal temporal lobe lesions alter recurrent functional connectivity within the ventral pathway during naming en_US
dc.type article en_US
dc.subject.eciencia Medicina es_ES
dc.subject.eciencia Psicología es_ES
dc.relation.publisherversion en_US
dc.identifier.doi 10.1523/JNEUROSCI.0645-13.2013 en_US
dc.identifier.publicationfirstpage 12679 es_ES
dc.identifier.publicationissue 33 es_ES
dc.identifier.publicationlastpage 12688 es_ES
dc.identifier.publicationvolume 31 es_ES
dc.relation.projectID Gobierno de España. SAF2011-27920 es_ES
dc.relation.projectID Gobierno de España. RYC-2010-05748 es_ES
dc.relation.projectID Gobierno de España. AP2009-4131 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion es_ES
dc.rights.accessRights openAccess en_US
dc.authorUAM Campo Martínez-Lage, Pablo (264681)
dc.authorUAM Igoa González, José Manuel (261500)
dc.authorUAM Poch Pérez-Botija, Claudia (264837)

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