Tubulin and actin interplay at thet cell and antigen-presenting cell interface

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dc.contributor.author Martín-Cófreces, Noa
dc.contributor.author Alarcón, Balbino
dc.contributor.author Sánchez-Madrid, Francisco
dc.contributor.other UAM. Departamento de Biología Molecular es_ES
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.date.accessioned 2015-07-06T11:38:40Z
dc.date.available 2015-07-06T11:38:40Z
dc.date.issued 2011-12-01
dc.identifier.citation Frontiers in Immunology 2 (2011): 24 en_US
dc.identifier.issn 1664-3224 es_ES
dc.identifier.uri http://hdl.handle.net/10486/667260
dc.description This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission en_US
dc.description.abstract T cells reorganize their actin and tubulin-based cytoskeletons to provide a physical basis to the immune synapse. However,growing evidence shows that their roles on Tcell activation are more dynamic than merely serving as tracks or scaffold for different mol-ecules.The crosstalk between both skeletons may be important for the formation and movement of the lamella at the immunological synapse by increasing the adhsion of the T cell to the antigen-presenting cells (APC), thus favoring the transport of components toward the plasma membrane and in turn regulating theT-APC intercellular communication. Microtubules and F-actin appear to be essential for the transport of thed ifferent signaling microclusters along the membrane, therefore facilitating the propagation of the signal. Finally,they can also be important for regulating the endocytosis, recycling, and degrada-tion of the Tcell receptor signaling machinery, thus helping both to sustain the activated state and to switch it off en_US
dc.description.sponsorship This work was supported by grantsf rom Spanish Ministry of Science and Innovation (SAF2008-02635), INSINET 0159/2006 from Comunidad de Madrid, Red RECAVARD 06/0014-0030, and the Centro Nacional de Investigaciones Cardiovasculares (CNIC, Spain), which is supported by the Spanish Ministry of Science and Innovation and the Pro-CNIC Foundation. en_US
dc.format.extent 6 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Frontiers Research Foundation en_US
dc.relation.ispartof Frontiers in Immunology en_US
dc.rights © 2011 Martín-Cófreces, Alarcón and Sánchez-Madrid es_ES
dc.subject.other Actin en_US
dc.subject.other Immune synapse en_US
dc.subject.other Microtubule-organizing centre en_US
dc.subject.other T cell en_US
dc.title Tubulin and actin interplay at thet cell and antigen-presenting cell interface en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.3389/fimmu.2011.00024 es_ES
dc.identifier.doi 10.3389/fimmu.2011.00024 es_ES
dc.identifier.publicationfirstpage 24 es_ES
dc.identifier.publicationlastpage 24 es_ES
dc.identifier.publicationvolume 2 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Sánchez Madrid, Francisco (259404)

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