The multifaceted poliovirus 2A protease: Regulation of gene expression by picornavirus proteases

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dc.contributor.author Castello, Alfredo
dc.contributor.author Álvarez, Enrique
dc.contributor.author Carrasco, Luis
dc.contributor.other UAM. Departamento de Biología Molecular es_ES
dc.date.accessioned 2015-08-05T08:50:24Z
dc.date.available 2015-08-05T08:50:24Z
dc.date.issued 2011-06-24
dc.identifier.citation Journal of Biomedicine and Biotechnology (2011): 369648 en_US
dc.identifier.issn 1110-7243 (print) en_US
dc.identifier.issn 1110-7251 (online) en_US
dc.identifier.uri http://hdl.handle.net/10486/667678
dc.description.abstract After entry into animal cells, most viruses hijack essential components involved in gene expression. This is the case of poliovirus, which abrogates cellular translation soon after virus internalization. Abrogation is achieved by cleavage of both eIF4GI and eIF4GII by the viral protease 2A. Apart from the interference of poliovirus with cellular protein synthesis, other gene expression steps such as RNA and protein trafficking between nucleus and cytoplasm are also altered. Poliovirus 2A pro is capable of hydrolyzing components of the nuclear pore, thus preventing an efficient antiviral response by the host cell. Here, we compare in detail poliovirus 2A pro with other viral proteins (from picornaviruses and unrelated families) as regard to their activity on key host factors that control gene expression. It is possible that future analyses to determine the cellular proteins targeted by 2A pro will uncover other cellular functions ablated by poliovirus infection. Further understanding of the cellular proteins hydrolyzed by 2A pro will add further insight into the molecular mechanism by which poliovirus and other viruses interact with the host cell en_US
dc.description.sponsorship Our group is supported by a DGICYT Grant (no. BFU2009-07352). The Institutional Grant awarded to the Centro de Biología Molecular “Severo Ochoa” by the Fundación Ramón Areces is also acknowledged. A. Castello is a beneficiary of Marie Curie IEF fellowship (Seventh Framework Programme). en_US
dc.format.extent 23 pag. en
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.ispartof Journal of Biomedicine and Biotechnology en_US
dc.rights Copyright © 2011 Alfredo Castelló et al. en_US
dc.subject.other Cell Nucleus en_US
dc.subject.other Cysteine Endopeptidases en_US
dc.subject.other Eukaryotic Initiation Factor-4G en_US
dc.subject.other Gene Expression Regulation en_US
dc.subject.other Poliovirus en_US
dc.subject.other Protein Biosynthesis en_US
dc.subject.other Protein Processing, Post-Translational en_US
dc.subject.other Structure-Activity Relationship en_US
dc.subject.other Transcription, Genetic en_US
dc.subject.other Viral Proteins en_US
dc.title The multifaceted poliovirus 2A protease: Regulation of gene expression by picornavirus proteases en_US
dc.type article en
dc.subject.eciencia Biología y Biomedicina / Biología es_ES
dc.relation.publisherversion http://dx.doi.org/10.1155/2011/369648 es_ES
dc.identifier.doi 10.1155/2011/369648 es_ES
dc.identifier.publicationfirstpage 369648 es_ES
dc.identifier.publicationlastpage 369648 es_ES
dc.identifier.publicationvolume 2011 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en


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