KIR2DL5: An orphan inhibitory receptor displaying complex patterns of polymorphism and expression

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dc.contributor.author Cisneros, Elisa
dc.contributor.author Moraru, Manuela
dc.contributor.author Gómez-Lozano, Natalia
dc.contributor.author Lopez-Botet, Miguel
dc.contributor.author Vilches, Carlos
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.date.accessioned 2015-11-25T15:52:02Z
dc.date.available 2015-11-25T15:52:02Z
dc.date.issued 2012-12-01
dc.identifier.citation Frontiers in Immunology 3 (2012): 289 en_US
dc.identifier.issn 1664-3224 es_ES
dc.identifier.uri http://hdl.handle.net/10486/668976
dc.description This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission en_US
dc.description.abstract A recently developed anti-KIR2DL5 (CD158f) antibody has demonstrated KIR2DL5 expression on the surface of NK andT lymphocytes, making it the last functional KIR identified in the human genome. KIR2DL5 belongs to an ancestral lineage of KIR with Ig-like domains of the D0-D2 type, of which KIR2DL4, an HLA-G receptor, is the only other human member. Despite KIR2DL4 and KIR2DL5 being encoded by genes with similar domain usage, several KIR2DL5 functions resemble more closely those of KIR recognizing classical HLA class I molecules – surface-expressed KIR2DL5 inhibits NK cells through the SHP-2 phosphatase and displays a clonal distribution on NK andT lymphocytes. No activating homolog of KIR2DL5 has been described in any species.The genetics of KIR2DL5 is complicated by duplication of its gene in an ancestor of modern humans living s1.7 million years ago. Both KIR2DL5 paralogs have undergone allelic diversification; the centromeric gene is most often represented by alleles whose expression is silenced epigenetically through DNA methylation, thus providing a natural system to investigate the regulation of KIR transcription. The role of KIR2DL5 in immunity is not completely understood, in spite of different attempts to define its ligand. Here we revisit the most relevant characteristics of KIR2DL5, an NK-cell receptor possessing a unique combination of genetic, structural, and functional features en_US
dc.description.sponsorship Research on KIR2DL5 was supported by successive grants from the Spanish Instituto de Salud Carlos III and Plan Nacional de ICD, including SAF2010-22153-C03 en_US
dc.format.extent 8 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Frontiers Research Foundation en_US
dc.relation.ispartof Frontiers in Immunology en_US
dc.rights © 2012 Cisneros, Moraru, Gómez-Lozano, López-Botetand and Vilches es_ES
dc.subject.other Gene polymorphism en_US
dc.subject.other Human NK cells en_US
dc.subject.other Inhibitory receptors en_US
dc.subject.other KIR en_US
dc.subject.other NK cell receptors en_US
dc.subject.other Transcription en_US
dc.title KIR2DL5: An orphan inhibitory receptor displaying complex patterns of polymorphism and expression en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.3389/fimmu.2012.00289 es_ES
dc.identifier.doi 10.3389/fimmu.2012.00289 es_ES
dc.identifier.publicationfirstpage 289-1 es_ES
dc.identifier.publicationlastpage 289-8 es_ES
dc.identifier.publicationvolume 3 es_ES
dc.relation.projectID Gobierno de España. SAF2010-22153-C03 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en


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