Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis

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dc.contributor.author Prieto-Potin, Iván
dc.contributor.author Largo, Raquel
dc.contributor.author Roman-Blas, Jorge A.
dc.contributor.author Herrero-Beaumont, Gabriel
dc.contributor.author Walsh, David A.
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) es_ES
dc.date.accessioned 2016-06-20T14:00:06Z
dc.date.available 2016-06-20T14:00:06Z
dc.date.issued 2015-08-27
dc.identifier.citation BMC Musculoskeletal Disorders 16 (2015): 226 es_ES
dc.identifier.issn 1471-2474 es_ES
dc.identifier.uri http://hdl.handle.net/10486/671560
dc.description.abstract Background: Multinucleated giant cells have been noticed in diverse arthritic conditions since their first description in rheumatoid synovium. However, their role in the pathogenesis of osteoarthritis (OA) or rheumatoid arthritis (RA) still remains broadly unknown. We aimed to study the presence and characteristics of multinucleated giant cells (MGC) both in synovium and in subchondral bone tissues of patients with OA or RA. Methods: Knee synovial and subchondral bone samples were from age-matched patients undergoing total joint replacement for OA or RA, or non-arthritic post mortem (PM) controls. OA synovium was stratified by histological inflammation grade using index tissue sections. Synovitis was assessed by Krenn score. Histological studies employed specific antibodies against macrophage markers or cathepsin K, or TRAP enzymatic assay. Results: Inflamed OA and RA synovia displayed more multinucleated giant cells than did non-inflamed OA and PM synovia. There was a significant association between MGC numbers and synovitis severity. A TRAP negative/ cathepsin K negative Langhans-like subtype was predominant in OA, whereas both Langhans-like and TRAP-positive/ cathepsin K-negative foreign-body-like subtypes were most commonly detected in RA. Plasma-like and foam-like subtypes also were observed in OA and RA synovia, and the latter was found surrounding adipocytes. TRAP positive/ cathepsin K positive osteoclasts were only identified adjacent to subchondral bone surfaces. TRAP positive osteoclasts were significantly increased in subchondral bone in OA and RA compared to PM controls. Conclusions: Multinucleated giant cells are associated with synovitis severity, and subchondral osteoclast numbers are increased in OA, as well as in RA. Further research targeting multinucleated giant cells is warranted to elucidate their contributions to the symptoms and joint damage associated with arthritis en_US
dc.description.sponsorship This work was partially supported by the Arthritis Research UK Pain Centre (Arthritis Research UK, grant number 18769) and by research grant from the Instituto Carlos III (PI13/00570 and PI12/00144). IP-P was funded by an ECTS exchange scholarship grant and an investigator mobility grant from the Autonomous University of Madrid. e
dc.format.extent 10 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng es_ES
dc.publisher BioMed Central es_ES
dc.relation.ispartof BMC Musculoskeletal Disorders es_ES
dc.rights © 2015 Prieto-Potin et al. es_ES
dc.subject.other Giant cells en_US
dc.subject.other Synovitis en_US
dc.subject.other Arthritis en_US
dc.title Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.1186/s12891-015-0664-5 es_ES
dc.identifier.doi 10.1186/s12891-015-0664-5 es_ES
dc.identifier.publicationfirstpage 226 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage 226 es_ES
dc.identifier.publicationvolume 16 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en_US
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Herrero-Beaumont Cuenca, Gabriel (259891)


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