Population-based multicase-control study in common tumors in Spain (MCC-Spain): Rationale and study design

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dc.contributor.author Castaño-Vinyals, Gemma
dc.contributor.author Aragonés, Nuria
dc.contributor.author Pérez-Gómez, Beatriz
dc.contributor.author Martín, Vicente
dc.contributor.author Llorca, Javier
dc.contributor.author Moreno, Víctor
dc.contributor.author Altzibar, Jone M.
dc.contributor.author Ardanaz, Eva
dc.contributor.author De Sanjosé, Sílvia
dc.contributor.author Jiménez-Moleón, José J.
dc.contributor.author Tardón, Adonina
dc.contributor.author Alguacil, Juan
dc.contributor.author Peiró, Rosana
dc.contributor.author Marcos-Gragera, Rafael
dc.contributor.author Navarro, Carmen
dc.contributor.author Pollán, Marina
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Alonso, Maria Teresa
dc.contributor.author Amiano, Pilar
dc.contributor.author Arias, Cristina
dc.contributor.author Azpiri, Mikel
dc.contributor.author Benavente, Yolanda
dc.contributor.author Boldo, Elena
dc.contributor.author Bueno, Aurora
dc.contributor.author Bustamante, Mariona
dc.contributor.author Caballero, Francisco Javier
dc.contributor.author Campo, Elías
dc.contributor.author Cantón, Rafael
dc.contributor.author Capelo, Rocío
dc.contributor.author Carmona, Carme
dc.contributor.author Casabonne, Delphine
dc.contributor.author Chirlaque, María Dolores
dc.contributor.author Cirac, Judith
dc.contributor.author Clofent, Juan
dc.contributor.author Colado, Enrique
dc.contributor.author Costas, Laura
dc.contributor.author Crous, Marta
dc.contributor.author Campo, Rosa del
dc.contributor.author Díaz Santos, Marian
dc.contributor.author Dierssen-Sotos, Trinidad
dc.contributor.author Ederra, María
dc.contributor.author Espinosa, Ana
dc.contributor.author Fernández Cabrera, Marieta
dc.contributor.author Fernández Somoano, Ana
dc.contributor.author Fernández Villa, Tania
dc.contributor.author García García-Esquinas, Esther
dc.contributor.author García Martín, Paloma
dc.contributor.author Gómez-Acebo, Inés
dc.contributor.author Puga, Cristina González
dc.contributor.author Gràcia, Esther
dc.contributor.author Eslava, Marcela Guevara
dc.contributor.author Guinó, Elisabet
dc.contributor.author Huerta, José María
dc.contributor.author Lope, Virginia
dc.contributor.author López-Abente, Gonzalo
dc.contributor.author López-Otín, Carlos
dc.contributor.author Martínez Argüelles, Begoña
dc.contributor.author Merino Salas, Sergio
dc.contributor.author Mirón Pozo, Benito
dc.contributor.author Molina dee La Torre, Antonio José
dc.contributor.author Moreno, Eduardo
dc.contributor.author Moreno Iribas, Concepción
dc.contributor.author Olea, Nicolás
dc.contributor.author Gelis, Gemma Osca
dc.contributor.author Paré, Laia
dc.contributor.author Porta, Miquel
dc.contributor.author Puig, Montse
dc.contributor.author Rivad del Fresno, Manuel
dc.contributor.author Robles, Claudia
dc.contributor.author Rodríguez Suarez, Marta María
dc.contributor.author Romero, Beatriz
dc.contributor.author Sáez Castillo, Ana Isabel
dc.contributor.author Sala Serra, Maria
dc.contributor.other UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología es_ES
dc.date.accessioned 2016-08-25T13:42:40Z
dc.date.available 2016-08-25T13:42:40Z
dc.date.issued 2015-01-01
dc.identifier.citation Gaceta Sanitaria 29.4 (2015): 308-315 es_ES
dc.identifier.issn 0213-9111 es_ES
dc.identifier.uri http://hdl.handle.net/10486/672463
dc.description.abstract Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain en_US
dc.description.sponsorship The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT- 2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the The Catalan Government DURSI grant 2009SGR1489 en_US
dc.format.extent 8 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Elsevier España, S.L.U. es_ES
dc.relation.ispartof Gaceta Sanitaria es_ES
dc.rights © 2014 SESPAS. es_ES
dc.subject.other Breast cancer en_US
dc.subject.other Case-control en_US
dc.subject.other Chronic lymphocytic leukemia en_US
dc.subject.other Colorectal cancer en_US
dc.subject.other Epidemiology en_US
dc.subject.other Gastric cancer en_US
dc.subject.other Prostate cancer en_US
dc.title Population-based multicase-control study in common tumors in Spain (MCC-Spain): Rationale and study design en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://dx.doi.org/10.1016/j.gaceta.2014.12.003 en
dc.identifier.doi 10.1016/j.gaceta.2014.12.003 es_ES
dc.identifier.publicationfirstpage 308 es_ES
dc.identifier.publicationissue 4 es_ES
dc.identifier.publicationlastpage 315 es_ES
dc.identifier.publicationvolume 29 es_ES
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/036224 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.accessRights openAccess en
dc.authorUAM Pollán Santamaría, Marina Anunciación (262007)
dc.authorUAM García García-Esquinas, Esther (279711)

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