Molecular chaperones of Leishmania: central players in many stress-related and -unrelated physiological processes

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dc.contributor.author Requena, Jose M.
dc.contributor.author Montalvo, Ana M.
dc.contributor.author Fraga, Jorge
dc.contributor.other UAM. Departamento de Biología Molecular es_ES
dc.date.accessioned 2017-05-04T10:41:04Z
dc.date.available 2017-05-04T10:41:04Z
dc.date.issued 2015-05-24
dc.identifier.citation BioMed Research International 2015 (2015): 301326 en_US
dc.identifier.issn 2314-6141 (online) es_ES
dc.identifier.issn 2314-6133 (print) es_ES
dc.identifier.uri http://hdl.handle.net/10486/678097
dc.description.abstract Molecular chaperones are key components in the maintenance of cellular homeostasis and survival, not only during stress but also under optimal growth conditions. Folding of nascent polypeptides is supported by molecular chaperones, which avoid the formation of aggregates by preventing nonspecific interactions and aid, when necessary, the translocation of proteins to their correct intracellular localization. Furthermore, when proteins are damaged, molecular chaperones may also facilitate their refolding or, in the case of irreparable proteins, their removal by the protein degradation machinery of the cell. During their digenetic lifestyle, Leishmania parasites encounter and adapt to harsh environmental conditions, such as nutrient deficiency, hypoxia, oxidative stress, changing pH, and shifts in temperature; all these factors are potential triggers of cellular stress. We summarize here our current knowledge on the main types of molecular chaperones in Leishmania and their functions. Among them, heat shock proteins play important roles in adaptation and survival of this parasite against temperature changes associated with its passage from the poikilothermic insect vector to the warm-blooded vertebrate host. The study of structural features and the function of chaperones in Leishmania biology is providing opportunities (and challenges) for drug discovery and improving of current treatments against leishmaniasis en_US
dc.description.sponsorship Work at the Jose M. Requena’s laboratory is funded by Ministerio de Economía y Competitividad-FEDER (Grant SAF2013-47556- R), the Network of Tropical Diseases Research RICET-ISCIII- FEDER(Grant RD12/0018/0009), and the Comunidad Autónoma de Madrid (Grant S2010/BMD-2361). An institutional grant from Ramon Areces is also acknowledged (Jose M. Requena’s ORCID ID: 0000-0003-3410-9488, Ana M. Montalvo’s ORCID ID: 0000-0003-1248-6215, and Jorge Fraga ORCID ID: 0000-0001-9061-2550). en_US
dc.format.extent 22 pág. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Hindawi Publishing Corporation en_US
dc.relation.ispartof BioMed Research International en_US
dc.rights © 2015 Jose M. Requena et al. en_US
dc.subject.other Molecular chaperones en_US
dc.subject.other Leishmania en_US
dc.subject.other Stress en_US
dc.subject.other Physiological processes en_US
dc.title Molecular chaperones of Leishmania: central players in many stress-related and -unrelated physiological processes en_US
dc.type article en
dc.subject.eciencia Biología y Biomedicina / Biología es_ES
dc.relation.publisherversion http://dx.doi.org/10.1155/2015/301326 es_ES
dc.identifier.doi 10.1155/2015/301326 es_ES
dc.identifier.publicationfirstpage 301326 es_ES
dc.identifier.publicationlastpage 301326 es_ES
dc.identifier.publicationvolume 2015 es_ES
dc.relation.projectID Gobierno de España. SAF2013-47556- R es_ES
dc.relation.projectID Comunidad de Madrid. S2010/BMD-2361/PRIM-POL es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en


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