Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location

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dc.contributor.author Brandariz, Lorena
dc.contributor.author Arriba, María
dc.contributor.author García, Juan Luis
dc.contributor.author Cano, Juana María
dc.contributor.author Rueda, Daniel
dc.contributor.author Rubio, Eduardo
dc.contributor.author Rodríguez, Yolanda
dc.contributor.author Pérez, Jessica
dc.contributor.author Vivas, Alfredo
dc.contributor.author Sánchez, Carmen
dc.contributor.author Tapial, Sandra
dc.contributor.author Pena, Laura
dc.contributor.author García-Arranz, Mariano
dc.contributor.author García-Olmo, Damián
dc.contributor.author Urioste, Miguel
dc.contributor.author González-Sarmiento, Rogelio
dc.contributor.author Perea, José
dc.contributor.other UAM. Departamento de Cirugía es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) es_ES
dc.contributor.other Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD) es_ES
dc.date.accessioned 2018-09-27T14:43:49Z
dc.date.available 2018-09-27T14:43:49Z
dc.date.issued 2018-01-01
dc.identifier.citation Oncotarget 9.20 (2018): 15302-15311 en_US
dc.identifier.issn 1949-2553 es_ES
dc.identifier.uri http://hdl.handle.net/10486/685204
dc.description.abstract Background: Since there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC). Results: Right colon cancers showed features associated with sporadic Microsatellite Instability: predominance of female cases and BRAF mutations, and an important mucinous component. Left colon cancers developed a higher number of polyps and multiple primary CRCs, showed the strongest familial component, and had better prognosis. Rectal cancers showed a predominantly sporadic phenotype, with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy number alterations (CNAs) greater than or equal to 50% were observed in this LOCRC group, and the most recurrent alterations were losses at 5q13 and 14q11, and gains at 7q11, 7q21-q22, 19p13-p12, 19q13 and 20p11-q11. KRAS and PIK3CA were the only mutated genes showing differences according to the tumor location, mainly for right colon cancers. Materials and Methods: We analyzed clinical and molecular characteristics of LOCRC at different tumor locations in order to determine if there are differential phenotypes related with the location in the colon. Conclusions: Categorizing LOCRC according to tumor location appears to be an adequate first step to resolving the heterogeneity of this subset of CRC en_US
dc.description.sponsorship This work was funded by Projects PI10/0683, PI13/01741, PI13/0127 and PI14/00459 from the Spanish Ministry of Health and Consumer Affairs and FEDER, and was approved by the Ethics Committee of our Institution en_US
dc.format.extent 10 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Impact Journals en_US
dc.relation.ispartof Oncotarget en_US
dc.rights © Brandariz et al es_ES
dc.subject.other Chromosomal instability en_US
dc.subject.other Colon location en_US
dc.subject.other CpG island methylator phenotype en_US
dc.subject.other Late-onset colorectal cancer en_US
dc.subject.other Microsatellite instability en_US
dc.title Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location en
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.18632/oncotarget.24502 es_ES
dc.identifier.doi 10.18632/oncotarget.24502 es_ES
dc.identifier.publicationfirstpage 15302 es_ES
dc.identifier.publicationissue 20 es_ES
dc.identifier.publicationlastpage 15311 es_ES
dc.identifier.publicationvolume 9 es_ES
dc.relation.projectID Gobierno de España. PI10/0683 es_ES
dc.relation.projectID Gobierno de España. PI13/0127 es_ES
dc.relation.projectID Gobierno de España. PI13/0127 es_ES
dc.relation.projectID Gobierno de España. PI14/00459 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en

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